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Description: Highly potent and selective CB2R agonist
Chemical Name: N-[(3E)-5-tert-Butyl-2-(cyclobutylmethyl)-1-methyl-1,2-dihydro-3H-pyrazol-3-ylidene]-2-(2-hydroxy-2-methylpropoxy)-5-(trifluoromethyl)benzamide
Purity: ≥97% (HPLC)
Biological Activity for RNB 61
RNB 61 is a highly potent and selective cannabinoid CB2 receptor (CB2R) agonist (Ki = 0.57 nM). RNB 61 shows >5000-fold selectivity for hCB2R over hCB1R. In vivo, RNB 61 inhibits the FSK-induced cAMP formation on mouse, rat, and dog CB2Rs (EC50 values ranging from 0.13 to 1.86 nM).
Technical Data for RNB 61
| M. Wt | 481.56 |
| Formula | C25H34F3N3O3 |
| Storage | Store at -20°C |
| Purity | ≥97% (HPLC) |
| CAS Number | 1217403-51-4 |
| PubChem ID | 66642909 |
| InChI Key | SHUYRGCUYVGFJV-XHLNEMQHSA-N |
| Smiles | O=C(C1=C(C=CC(C(F)(F)F)=C1)OCC(C)(O)C)/N=C2N(N(C(C(C)(C)C)=C/2)C)CC3CCC3 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for RNB 61
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 24.08 | 50 | |
| ethanol | 48.16 | 100 |
Preparing Stock Solutions for RNB 61
The following data is based on the product molecular weight 481.56. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.08 mL | 10.38 mL | 20.77 mL |
| 5 mM | 0.42 mL | 2.08 mL | 4.15 mL |
| 10 mM | 0.21 mL | 1.04 mL | 2.08 mL |
| 50 mM | 0.04 mL | 0.21 mL | 0.42 mL |
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Product Datasheets for RNB 61
References for RNB 61
References are publications that support the biological activity of the product.
Chicca et al (2024) A highly potent, orally bioavailable pyrazole-derived cannabinoid CB2 receptor- selective full agonist for in vivo studies. ACS Pharmacol.Transl.Sci. 7 2424 PMID: 39144568
If you know of a relevant reference for RNB 61, please let us know.
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Citations for RNB 61
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Cannabinoid Receptor Ligands Scientific Review
Written by Roger Pertwee, this review discusses compounds which affect the activity of the endocannabinoid system, focusing particularly on ligands that are most widely used as experimental tools and denotes compounds available from Tocris.