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Submit ReviewRo 01-6128
Discontinued Product
4348 has been discontinued.
View all Glutamate (Metabotropic) Group I Receptors products.
Description: Positive allosteric modulator of mGlu1 receptors
Chemical Name: (Diphenylacetyl)-carbamic acid ethy ester
Purity: ≥98% (HPLC)
Biological Activity for Ro 01-6128
Ro 01-6128 is a positive allosteric modulator of mGlu1 receptors. Potentiates glutamate-induced calcium release (EC50 = 104.2 nM at rat mGluR1a).
Technical Data for Ro 01-6128
| M. Wt | 283.32 |
| Formula | C17H17NO3 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 302841-86-7 |
| PubChem ID | 9903898 |
| InChI Key | ILSZPWZFQHSKLW-UHFFFAOYSA-N |
| Smiles | O=C(NC(OCC)=O)C(C2=CC=CC=C2)C1=CC=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Ro 01-6128
References for Ro 01-6128
References are publications that support the biological activity of the product.
Knoflach et al (2001) Positive allosteric modulators of metabotropic glutamate 1 receptor: characterization, mechanism of action, and binding site. Proc.Natl.Acad.Sci.USA 98 13402 PMID: 11606768
Hemstapat et al (2006) A novel class of positive allosteric modulators of metabotropic glutamate receptor subtype 1 interact with a site distinct from that of negative allosteric modulators. Mol.Pharmacol. 70 616 PMID: 16645124
Brock et al (2007) Activation of a dimeric metabotropic glutamate receptor by intersubunit rearrangement. J.Biol.Chem. 282 33000 PMID: 17855348
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Keywords: Ro 01-6128, Ro 01-6128 supplier, Ro01-6128, metabotropic, glutamate, mglu1, mglur1, pam, positive, allosteric, modulators, potentiators, Glutamate, (Metabotropic), Group, I, Receptors, 4348, Tocris Bioscience
Citations for Ro 01-6128
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Currently there are no citations for Ro 01-6128.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Metabotropic Glutamate Receptors Scientific Review
Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.
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