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Submit ReviewRo 04-5595 hydrochloride
Description: GluN2B-selective NMDA antagonist
Chemical Name: 1-[2-(4-Chlorophenyl)ethyl]-1,2,3,4-tetrahydro-6-methoxy-2-methyl-7-isoquinolinol hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for Ro 04-5595 hydrochloride
Ro 04-5595 hydrochloride is a selective antagonist for GluN2B (formally NR2B) containing NMDA receptors (Ki = 31 nM).
Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.
Technical Data for Ro 04-5595 hydrochloride
| M. Wt | 368.3 |
| Formula | C19H22ClNO2.HCl |
| Storage | Desiccate at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 64047-73-0 |
| PubChem ID | 46739 |
| InChI Key | NVIPBLQAFKRFSZ-UHFFFAOYSA-N |
| Smiles | Cl.COC1=CC2=C(C=C1O)C(CCC1=CC=C(Cl)C=C1)N(C)CC2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Ro 04-5595 hydrochloride
References for Ro 04-5595 hydrochloride
References are publications that support the biological activity of the product.
Mutel et al (1998) In vitro binding properties in rat brain of [3H] Ro 25-6981, a potent and selective antagonist of NMDA receptors containing NR2B subunits. J.Neurochem. 70 214
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Keywords: Ro 04-5595 hydrochloride, Ro 04-5595 hydrochloride supplier, Selective, NR2B, antagonists, Glutamate, NMDA, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, Ro04-5595, hydrochloride, GluN2B, 2005, Tocris Bioscience
1 Citation for Ro 04-5595 hydrochloride
Citations are publications that use Tocris products. Selected citations for Ro 04-5595 hydrochloride include:
Voyer (2017) Repeated ventral midbrain neurotensin injections sensitize to amphetamine-induced locomotion and ERK activation: A role for NMDA receptors Neuropharmacology 112 150 PMID: 27267684
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