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Submit ReviewRo 10-5824 dihydrochloride
Description: Selective D4 partial agonist
Chemical Name: 5-[(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)methyl]-2-methyl-4-pyrimidinamine dihydrochloride
Purity: ≥99% (HPLC)
Biological Activity for Ro 10-5824 dihydrochloride
Ro 10-5824 dihydrochloride is a selective dopamine D4 receptor partial agonist (EC50 = 205 nM) that binds with high affinity (Ki = 5.2 nM). Displays 250-fold selectivity over D3 receptors and > 1000-fold selectivity over D2, D1 and D5 receptors.
Technical Data for Ro 10-5824 dihydrochloride
| M. Wt | 353.29 |
| Formula | C17H20N4.2HCl |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 189744-94-3 |
| PubChem ID | 16759174 |
| InChI Key | UZHMRJRDYCRKIZ-UHFFFAOYSA-N |
| Smiles | Cl.Cl.CC1=NC=C(CN2CCC(=CC2)C2=CC=CC=C2)C(N)=N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Ro 10-5824 dihydrochloride
References for Ro 10-5824 dihydrochloride
References are publications that support the biological activity of the product.
Powell et al (2003) RO-10-5824 is a selective DA D4 receptor agonist that increases novel object exploration in C57 mice. Neuropharmacology 44 473 PMID: 12646284
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Keywords: Ro 10-5824 dihydrochloride, Ro 10-5824 dihydrochloride supplier, Selective, D4, receptor, partial, agonists, Dopamine, Receptors, dopaminergic, Ro10-5824, dihydrochloride, 2329, Tocris Bioscience
1 Citation for Ro 10-5824 dihydrochloride
Citations are publications that use Tocris products. Selected citations for Ro 10-5824 dihydrochloride include:
Navakkode et al (2017) Bidirectional modulation of hippocampal synaptic plasticity by Dopaminergic D4-receptors in the CA1 area of hippocampus. Sci Rep 7 15571 PMID: 29138490
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Dopamine Receptors Scientific Review
Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.
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