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Submit ReviewRo 15-4513
Description: Benzodiazepine partial inverse agonist
Chemical Name: 8-Azido-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid ethyl ester
Purity: ≥98% (HPLC)
Biological Activity for Ro 15-4513
Ro 15-4513 is a high affinity benzodiazepine ligand. Ki values are 3.1 and 5.3 nM for diazepam-insensitive (DI) and diazepam-sensitive (DS) benzodiazepine receptors respectively. Acts as partial inverse agonist at recombinant DS α1-, α2-, α3- and α5-GABAA receptors. Displays partial agonism at DI α4- and α6-GABAA receptors. Antagonizes several behavioral and neurochemical effects of ethanol. Proconvulsant and anxiogenic.
Technical Data for Ro 15-4513
| M. Wt | 326.31 |
| Formula | C15H14N6O3 |
| Storage | Desiccate at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 91917-65-6 |
| PubChem ID | 5081 |
| InChI Key | CFSOJZTUTOQNIA-UHFFFAOYSA-N |
| Smiles | CCOC(=O)C1=C2CN(C)C(=O)C3=C(C=CC(=C3)N=[N+]=[N-])N2C=N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Ro 15-4513
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| ethanol | 1.63 | 5 | |
| DMSO | 3.26 | 10 |
Preparing Stock Solutions for Ro 15-4513
The following data is based on the product molecular weight 326.31. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 30.65 mL | 153.23 mL | 306.46 mL |
| 0.5 mM | 6.13 mL | 30.65 mL | 61.29 mL |
| 1 mM | 3.06 mL | 15.32 mL | 30.65 mL |
| 5 mM | 0.61 mL | 3.06 mL | 6.13 mL |
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Product Datasheets for Ro 15-4513
References for Ro 15-4513
References are publications that support the biological activity of the product.
Suzdak et al (1986) A selective imidazobenzodiazepine antagonist of ethanol in the rat. Science 234 1243 PMID: 3022383
Wong and Skolnick (1992) High affinity ligands for 'D.pam-insensitive' benzodiazepine receptors. Eur.J.Pharmacol. 225 63 PMID: 1311690
Knoflach et al (1996) Pharmacological modulation of the D.pam-insensitive recombinant gamma-aminobutyric acidA receptors alpha 4 beta 2 gamma 2 and alpha 6 beta 2 gamma 2. Mol.Pharmacol. 50 1253 PMID: 8913357
If you know of a relevant reference for Ro 15-4513, please let us know.
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Keywords: Ro 15-4513, Ro 15-4513 supplier, Benzodiazepine, partial, inverse, agonists, GABAA, Receptors, Ro15-4513, 1997, Tocris Bioscience
2 Citations for Ro 15-4513
Citations are publications that use Tocris products. Selected citations for Ro 15-4513 include:
Koh et al (2013) Selective GABA(A) α5 positive allosteric modulators improve cognitive function in aged rats with memory impairment. J Neurosci 64 145 PMID: 22732440
Tracy et al (2016) Negative allosteric modulation of GABAA receptors inhibits facilitation of brain stimulation reward by drugs of abuse in C57BL6/J mice. Psychopharmacology 233 715 PMID: 26612620
Do you know of a great paper that uses Ro 15-4513 from Tocris? Please let us know.
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