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Submit ReviewRo 19-4603
Description: Benzodiazepine inverse agonist
Chemical Name: 5,6-Dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a]thieno[2,3-f][1,4]diazepine-3-carboxylic acid 1,1-dimethylethyl ester
Purity: ≥99% (HPLC)
Biological Activity for Ro 19-4603
Benzodiazepine inverse agonist. Binds with high affinity to both diazepam-sensitive (DS) and diazepam-insensitive (DI) GABAA receptors (Ki values are ~ 0.2 and ~ 2.6 nM for DS and DI receptors respectively). Antagonizes effects of ethanol on locomotor behavior and suppresses ethanol intake in alcohol-preferring rats.
Technical Data for Ro 19-4603
| M. Wt | 319.38 |
| Formula | C15H17N3O3S |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 99632-94-7 |
| PubChem ID | 127382 |
| InChI Key | ZIGMMUKDYCABPW-UHFFFAOYSA-N |
| Smiles | CN1CC2=C(N=CN2C2=C(SC=C2)C1=O)C(=O)OC(C)(C)C |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Ro 19-4603
References for Ro 19-4603
References are publications that support the biological activity of the product.
Wong and Skolnick (1992) High affinity ligands for 'D.pam-insensitive' benzodiazepine receptors. Eur.J.Pharmacol. 225 63 PMID: 1311690
June et al (1995) Effects of the benzodiazepine inverse agonist RO19-4603 on the maintenance of tolerance to a single dose of ethanol. J.Pharmacol.Exp.Ther. 274 1105 PMID: 7562476
June et al (1998) The novel benzodiazepine inverse agonist RO19-4603 antagonises ethanol motivated behaviours: neuropharmacological studies. Brain Res. 784 256 PMID: 9518641
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Keywords: Ro 19-4603, Ro 19-4603 supplier, Benzodiazepine, inverse, agonists, GABAA, Receptors, Ro19-4603, 1995, Tocris Bioscience
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