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Submit ReviewRo 26-4550 trifluoroacetate
Description: Competitive inhibitor of IL-2/ IL-2Rα receptor interaction
Chemical Name: N-[[(3R)-1-(Aminoiminomethyl)-3-piperidinyl]acetyl]-4-(phenylethynyl)-L-phenylalanine methyl ester trifluoroacetate
Purity: ≥98% (HPLC)
Biological Activity for Ro 26-4550 trifluoroacetate
Competitive reversible inhibitor of interleukin-2 (IL-2) binding to its receptor (IC50 = 3 μM for inhibition of IL-2 interaction with IL-2R α-subunit). Appears to compete with IL-2Rα for its binding site on IL-2.
Technical Data for Ro 26-4550 trifluoroacetate
| M. Wt | 560.57 |
| Formula | C26H30N4O3.CF3CO2H |
| Storage | Desiccate at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1217448-66-2 |
| PubChem ID | 16760522 |
| InChI Key | BVMWPONRCOSTMK-RFPXDPOKSA-N |
| Smiles | FC(F)(F)C(O)=O.NC(N1CCC[C@H](CC(N[C@H](C(OC)=O)CC2=CC=C(C#CC3=CC=CC=C3)C=C2)=O)C1)=N |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Ro 26-4550 trifluoroacetate
References for Ro 26-4550 trifluoroacetate
References are publications that support the biological activity of the product.
Braisted et al (2003) Discovery of a potent small molecule IL-2 inhibitor through fragment assembly. J.Am.Chem.Soc. 125 3714 PMID: 12656598
Tilley et al (1997) Identification of a small molecule inhibitor of the IL-2/IL-2Rα receptor interaction which binds to IL-2. J.Am.Chem.Soc. 119 7589
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Citations for Ro 26-4550 trifluoroacetate
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Currently there are no citations for Ro 26-4550 trifluoroacetate.
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