Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewRo 51
Description: Potent P2X3 and P2X2/3 antagonist
Chemical Name: 2-[[4-Amino-5-[5-iodo-4-methoxy-2-(1-methylethyl)phenoxy]-2,4-pyrimidinyl]amino]-1,3-propanediol
Purity: ≥98% (HPLC)
Biological Activity for Ro 51
Ro 51 is a potent, dual P2X3 and P2X2/3 antagonist (IC50 values are 2 and 5 nM for rP2X3 and hP2X2/3 respectively). Selective for P2X3 and P2X2/3 over other P2X receptors (IC50 values are > 10 μM for P2X1, P2X2, P2X4, P2X5, and P2X7). Cell permeable.
Technical Data for Ro 51
| M. Wt | 474.29 |
| Formula | C17H23IN4O4 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1050670-85-3 |
| PubChem ID | 24883277 |
| InChI Key | PAYROHWFGZADBR-UHFFFAOYSA-N |
| Smiles | NC1=NC(NC(CO)CO)=NC=C1OC2=C(C(C)C)C=C(OC)C(I)=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Ro 51
References for Ro 51
References are publications that support the biological activity of the product.
Jahangir et al (2009) Identification and SAR of novel diaminopyrimidines. Part 2: The discovery of RO-51, a potent and selective, dual P2X3/P2X2/3 antagonist for the treatment of pain. Bioorg.Med.Chem.Lett. 19 1632 PMID: 19231178
Syed and Kennedy (2012) Pharmacology of P2X receptors WIREs.Membr.Transp.Signal. 1 16
View Related Products by Target
View Related Products by Product Action
Keywords: Ro 51, Ro 51 supplier, Ro51, Potent, selective, P2X3, P2X2/3, P2X, purinergic, receptors, antagonists, purinoceptors, Receptors, 4391, Tocris Bioscience
1 Citation for Ro 51
Citations are publications that use Tocris products. Selected citations for Ro 51 include:
Lu et al (2019) Adenosine triphosphate is co-secreted with glucagon-like peptide-1 to modulate intestinal enterocytes and afferent neurons. Nat.Commun. 10 1029 PMID: 30833673
Reviews for Ro 51
There are currently no reviews for this product. Be the first to review Ro 51 and earn rewards!
Have you used Ro 51?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
P2X and P2Y Receptors Scientific Review
Written by Kenneth Jacobson, this review provides an overview of the different subtypes and structures of the P2 receptor families, as well as the pharmacological probes used to study them; compounds available from Tocris are listed.