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Submit ReviewRo 67-4853
Description: Positive allosteric modulator of group I mGlu receptors
Chemical Name: (9H-Xanthen-9-ylcarbonyl)-carbamic acid butyl ester
Purity: ≥99% (HPLC)
Biological Activity for Ro 67-4853
Ro 67-4853 is a positive allosteric modulator of mGlu group I receptors (pEC50 value is 7.16 for the rat mGlu1a receptor). Exhibits activity at all group I receptors, including human and rat mGlu1 and rat mGlu5. Enhances the effects of (S)-DHPG in CA3 neurons (EC50 = 95 nM).
Technical Data for Ro 67-4853
| M. Wt | 325.36 |
| Formula | C19H19NO4 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 302841-89-0 |
| PubChem ID | 9949202 |
| InChI Key | RQBUXEUMZZQUFY-UHFFFAOYSA-N |
| Smiles | O=C(NC(OCCCC)=O)C2C3=C(C=CC=C3)OC1=CC=CC=C12 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Ro 67-4853
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 32.54 | 100 |
Preparing Stock Solutions for Ro 67-4853
The following data is based on the product molecular weight 325.36. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.07 mL | 15.37 mL | 30.74 mL |
| 5 mM | 0.61 mL | 3.07 mL | 6.15 mL |
| 10 mM | 0.31 mL | 1.54 mL | 3.07 mL |
| 50 mM | 0.06 mL | 0.31 mL | 0.61 mL |
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Product Datasheets for Ro 67-4853
References for Ro 67-4853
References are publications that support the biological activity of the product.
Knoflach et al (2001) Positive allosteric modulators of metabotropic glutamate receptor: Characterizationn, mechanism of action, and binding site. Proc.Natl.Acad.Sci. 98 13402 PMID: 11606768
Hempstapat et al (2006) A novel class of positive allosteric modulators of metabotropic glutamate receptor subtype 1 interact with a site distinct from that of negative allosteric modulators. Mol.Pharmacol. 70 616 PMID: 16645124
If you know of a relevant reference for Ro 67-4853, please let us know.
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Keywords: Ro 67-4853, Ro 67-4853 supplier, Ro67-4853, PAM, positive, allosteric, modulator, modulators, metabotropic, glutamate, receptor, 1, enhancer, mGlu1, receptors, Glutamate, (Metabotropic), Group, I, Receptors, 4347, Tocris Bioscience
Citations for Ro 67-4853
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