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Submit ReviewRo 67-7476
Description: Positive allosteric modulator of mGlu1 receptors
Chemical Name: (2S)-2-(4-Fluorophenyl)-1-[(4-methylphenyl)sulfonyl]-pyrrolidine
Purity: ≥99% (HPLC)
Biological Activity for Ro 67-7476
Ro 67-7476 is a positive allosteric modulator of mGlu1 receptors. Potentiates glutamate-induced calcium release (EC50 = 60.1 nM at rat mGluR1a). Displays no activity at human mGlu1 receptors.
Compound Libraries for Ro 67-7476
Ro 67-7476 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for Ro 67-7476
| M. Wt | 319.39 |
| Formula | C17H18FNO2S |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 298690-60-5 |
| PubChem ID | 32681978 |
| InChI Key | DAEHFYNGSSBGSS-KRWDZBQOSA-N |
| Smiles | FC(C=C2)=CC=[C@@]2[C@@H]1CCCN1S(C3=CC=C(C)C=C3)(=O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Ro 67-7476
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 31.94 | 100 |
Preparing Stock Solutions for Ro 67-7476
The following data is based on the product molecular weight 319.39. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.13 mL | 15.65 mL | 31.31 mL |
| 5 mM | 0.63 mL | 3.13 mL | 6.26 mL |
| 10 mM | 0.31 mL | 1.57 mL | 3.13 mL |
| 50 mM | 0.06 mL | 0.31 mL | 0.63 mL |
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Product Datasheets for Ro 67-7476
References for Ro 67-7476
References are publications that support the biological activity of the product.
Hemstapat et al (2006) A novel class of positive allosteric modulators of metabotropic glutamate receptor subtype 1 interact with a site distinct from that of negative allosteric modulators. Mol.Pharmacol. 70 616 PMID: 16645124
Knoflach et al (2001) Positive allosteric modulators of metabotropic glutamate 1 receptor: characterization, mechanism of action, and binding site. Proc.Natl.Acad.Sci.USA 98 13402 PMID: 11606768
If you know of a relevant reference for Ro 67-7476, please let us know.
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Keywords: Ro 67-7476, Ro 67-7476 supplier, Ro67-7476, mglur1a, positive, allosteric, modulators, pams, Glutamate, (Metabotropic), Group, I, Receptors, 4346, Tocris Bioscience
2 Citations for Ro 67-7476
Citations are publications that use Tocris products. Selected citations for Ro 67-7476 include:
Wanxia et al (2021) BACE1 controls synaptic function through modulating release of synaptic vesicles. Mol Psychiatry 26 6394-6410 PMID: 34158621
Bariselli et al (2016) SHANK3 controls maturation of social reward circuits in the VTA. Nat Neurosci 19 926 PMID: 27273769
Do you know of a great paper that uses Ro 67-7476 from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Metabotropic Glutamate Receptors Scientific Review
Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.
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