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Submit ReviewRopinirole
Description: Selective D2-like agonist
Chemical Name: 4-[2-(Dipropylamino)ethyl]-1,3-dihydro-2H-indol-2-one hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for Ropinirole
Ropinirole is a selective D2-like receptor agonist (D3 > D2 > D4). Causes biphasic spontaneous locomotor activity and contralateral circling in 6-OHDA-lesioned mice. Displays anti-Parkinsonian activity.
Technical Data for Ropinirole
| M. Wt | 296.84 |
| Formula | C16H24N2O.HCl |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 91374-20-8 |
| PubChem ID | 68727 |
| InChI Key | XDXHAEQXIBQUEZ-UHFFFAOYSA-N |
| Smiles | O=C2NC1=CC=CC(CCN(CCC)CCC)=C1C2.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Ropinirole
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 29.68 | 100 | |
| DMSO | 14.84 | 50 |
Preparing Stock Solutions for Ropinirole
The following data is based on the product molecular weight 296.84. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.37 mL | 16.84 mL | 33.69 mL |
| 5 mM | 0.67 mL | 3.37 mL | 6.74 mL |
| 10 mM | 0.34 mL | 1.68 mL | 3.37 mL |
| 50 mM | 0.07 mL | 0.34 mL | 0.67 mL |
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Product Datasheets for Ropinirole
References for Ropinirole
References are publications that support the biological activity of the product.
Eden et al (1991) Preclinical pharmacology of ropin. (SK&F 101468-A) a novel DA D2 agonist. Pharmacol.Biochem.Behav. 38 147 PMID: 1673248
Tulloch (1997) Pharmacologic profile of ropinirole: a nonergoline DA agonist. Neurology 49 S58 PMID: 9222275
If you know of a relevant reference for Ropinirole, please let us know.
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Keywords: Ropinirole, Ropinirole supplier, Selective, D2-like, agonists, non-selective, dopamine, receptors, dopaminergic, Non-selective, Dopamine, 3680, Tocris Bioscience
1 Citation for Ropinirole
Citations are publications that use Tocris products. Selected citations for Ropinirole include:
Stefan et al (2021) New phosphosite-specific antibodies to unravel the role of GRK phosphorylation in dopamine D2 receptor regulation and signaling. Sci Rep 11 8288 PMID: 33859231
Do you know of a great paper that uses Ropinirole from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Dopamine Receptors Scientific Review
Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.