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Submit ReviewROS 234 dioxalate
Discontinued Product
2034 has been discontinued.
View all Histamine H<sub>3</sub> Receptors products.
Description: Potent H3 antagonist
Chemical Name: N-[3-(1H-Imidazol-4-yl)propyl]-1H-benzimidazol-2-amine dioxalate
Purity: ≥99% (HPLC)
Biological Activity for ROS 234 dioxalate
ROS 234 dioxalate is a potent H3 antagonist (pKB at guinea-pig ileum H3-receptor = 9.46). Limited blood brain barrier permeability (ED50 = 19.12 mg/kg i.p.).
Technical Data for ROS 234 dioxalate
| M. Wt | 421.37 |
| Formula | C13H15N5.2C2H2O4 |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 1781941-93-2 |
| PubChem ID | 56972188 |
| InChI Key | JKTBCMILCFDKEJ-UHFFFAOYSA-N |
| Smiles | O=C(O)C(O)=O.O=C(O)C(O)=O.C1(CCCNC2=NC3=C(C=CC=C3)N2)=CNC=N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for ROS 234 dioxalate
References for ROS 234 dioxalate
References are publications that support the biological activity of the product.
Ballabeni et al (2002) CNS access of selected H3-antagonists: ex vivo binding study in rats. Inflamm.Res. 51 S55 PMID: 12013409
Mor et al (2004) Synthesis, biological activity, QSAR and QSPR study of 2-aminobenzimidazole derivatives as potent H3-antagonists. Bioorg.Med.Chem.Lett. 12 663
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Keywords: ROS 234 dioxalate, ROS 234 dioxalate supplier, Potent, H3, antagonists, Receptors, Histamine, histaminergic, ROS234, dioxalate, 2034, Tocris Bioscience
Citations for ROS 234 dioxalate
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Histamine Receptors Scientific Review
Written by Iwan de Esch and Rob Leurs, this review provides a synopsis of the different histamine receptor subtypes and the ligands that act upon them; compounds available from Tocris are listed.
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