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RS 100329 hydrochloride

Cat. No. 1325 3 Citations Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Potent, subtype-selective α1A antagonist
Chemical Name: 5-Methyl-3-[3-[3-[4-[2-(2,2,2,-trifluroethoxy)phenyl]-1-piperazinyl]propyl]-2,4-(1H,3H)-pyrimidinedione hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (3)
Reviews
Literature (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for RS 100329 hydrochloride

RS 100329 hydrochloride is a subtype-selective α1A-adrenoceptor antagonist (pKi = 9.6 for human cloned α1A receptors). Displays 126- and 50-fold selectivity over human α1B and α1D receptors respectively. Active in vivo.

Licensing Information

Sold with the permission of Roche Bioscience

Technical Data for RS 100329 hydrochloride

M. Wt 462.89
Formula C20H25F3N4O3.HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 1215654-26-4
PubChem ID 11340200
InChI Key CWVABCXVOAVUJL-UHFFFAOYSA-N
Smiles Cl.CC1=CNC(=O)N(CCCN2CCN(CC2)C2=C(OCC(F)(F)F)C=CC=C2)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for RS 100329 hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 100

Preparing Stock Solutions for RS 100329 hydrochloride

The following data is based on the product molecular weight 462.89. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.16 mL 10.8 mL 21.6 mL
5 mM 0.43 mL 2.16 mL 4.32 mL
10 mM 0.22 mL 1.08 mL 2.16 mL
50 mM 0.04 mL 0.22 mL 0.43 mL

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Product Datasheets for RS 100329 hydrochloride

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References for RS 100329 hydrochloride

References are publications that support the biological activity of the product.

Conley et al (2001) The role of α1-adrenoceptors and 5-HT1A receptors in the control of the micturition reflex in male anaesthetized rats. Br.J.Pharmacol. 133 61 PMID: 11325795

Shannon Kava et al (1998) α1L-Adrenoceptor mediation of smooth muscle contraction in rabbit bladder neck: a model for lower urinary tract tissues of man. Br.J.Pharmacol. 123 1359 PMID: 9579731

Williams et al (1999) In vitro α1-adrenoceptor pharmacology of Ro 70-0004 and RS-100329, novel α1A-adrenoceptor selective antagonists. Br.J.Pharmacol. 127 252 PMID: 10369480

If you know of a relevant reference for RS 100329 hydrochloride, please let us know.

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3 Citations for RS 100329 hydrochloride

Citations are publications that use Tocris products. Selected citations for RS 100329 hydrochloride include:

Ishii and Sugimura (2015) Identification of a new pharmacological activity of the phenylpiperazine derivative naftopidil: tubulin-binding drug. Front Cell Neurosci 8 42618 PMID: 25584077

Zacharia et al (2013) High vascular tone of mouse femoral arteries in vivo is determined by sympathetic nerve activity via α1A- and α1D-adrenoceptor subtypes. PLoS One 8 e65969 PMID: 23776582

Cleary et al (2004) Sympathectomy reveals alpha 1A- and alpha 1D-adrenoceptor components to contractions to noradrenaline in rat vas deferens. Br J Pharmacol 143 745 PMID: 15451776

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Literature in this Area

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Depression Poster

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.