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Discontinued Product
1073 has been discontinued.
View all Glutamate (Metabotropic) Group II Receptors products.
Description: Selective group II mGlu antagonist
Chemical Name: (RS)-1-Amino-5-phosphonoindan-1-carboxylic acid
Biological Activity for (RS)-APICA
(RS)-APICA is a rigidified analog of MPPG (Cat. No. 0853); selective group II metabotropic glutamate receptor antagonist (IC50 = 30 μM) with no significant effect on group I and III mGlu receptors at concentrations up to 1 mM. Increases extracellular glutamate concentrations and possesses unusual inverse agonist-like action.
Technical Data for (RS)-APICA
| M. Wt | 257.18 |
| Formula | C10H12NO5P |
| Storage | Desiccate at +4°C |
| CAS Number | 170847-18-4 |
| PubChem ID | 4694355 |
| InChI Key | ZNQZXIHSJUDIKL-UHFFFAOYSA-N |
| Smiles | NC2(C(O)=O)CCC1=CC(P(O)(O)=O)=CC=C12 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for (RS)-APICA
References for (RS)-APICA
References are publications that support the biological activity of the product.
Krenz et al (2000) Group I, II and III mGluR compounds affect rhythm generation in the gastric circuit of the crustacean stomatogastric ganglion. J.Neurophysiol. 83 1188 PMID: 10712449
Xi et al (2002) Group II metabotropic glutamate receptors modulate extracellular glutamate in the nucleus accumbens. J.Pharmacol.Exp.Ther. 300 162 PMID: 11752112
Ma et al (1997) Synthesis and biological activity of cyclic analogues of MPPG and MCPG as metabotropic glutamate receptor antagonists. Bioorg.Med.Chem.Lett. 7 1195
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Keywords: (RS)-APICA, (RS)-APICA supplier, Selective, group, II, antagonists, mGlur, Group, Receptors, mGlu2, mGlu3, mGluR2, mGluR3, Glutamate, Metabotropic, (Metabotropic), 1073, Tocris Bioscience
2 Citations for (RS)-APICA
Citations are publications that use Tocris products. Selected citations for (RS)-APICA include:
Scholler (2017) HTS-compatible FRET-based conformational sensors clarify membrane receptor activation. Nat Chem Biol 13 372 PMID: 28135236
Jiang et al (2006) Activation of group III metabotropic glutamate receptors attenuates rotenone toxicity on DArgic neurons through a microtubule-dependent mechanism. J Neurosci 26 4318 PMID: 16624952
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Metabotropic Glutamate Receptors Scientific Review
Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.
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