Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit Review(RS)-MCPG disodium salt
Description: Non-selective mGlu antagonist; disodium salt of (RS)-MCPG (Cat. No. 0336)
Chemical Name: (RS)-α-Methyl-4-carboxyphenylglycine disodium salt
Purity: ≥99% (HPLC)
Biological Activity for (RS)-MCPG disodium salt
(RS)-MCPG disodium salt is a sodium salt of (RS)-MCPG, a non-selective group I/group II metabotropic glutamate receptor antagonist.
S-enantiomer also available.
Technical Data for (RS)-MCPG disodium salt
| M. Wt | 253.16 |
| Formula | C10H9NNa2O4 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| PubChem ID | 90488871 |
| InChI Key | YGOTXTUQJLFNHB-UHFFFAOYSA-L |
| Smiles | [Na+].[Na+].CC(N)(C([O-])=O)C1=CC=C(C=C1)C([O-])=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for (RS)-MCPG disodium salt
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 25.32 | 100 |
Preparing Stock Solutions for (RS)-MCPG disodium salt
The following data is based on the product molecular weight 253.16. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.95 mL | 19.75 mL | 39.5 mL |
| 5 mM | 0.79 mL | 3.95 mL | 7.9 mL |
| 10 mM | 0.4 mL | 1.98 mL | 3.95 mL |
| 50 mM | 0.08 mL | 0.4 mL | 0.79 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets for (RS)-MCPG disodium salt
References for (RS)-MCPG disodium salt
References are publications that support the biological activity of the product.
Collingridge and Watkins (1994) Phenylglycine derivatives as metabotropic glutamate receptor antagonists. TiPS 15 333 PMID: 7992387
Joly et al (1995) Molecular, functional and pharmacological characterization of the metabotropic glutamate receptor Type 5 splice variants: comparison with mGluR1. J.Neurosci. 15 3970 PMID: 7751958
Eaton et al (1993) Competitive antagonist at metabotropic glutamate receptors by (S)-4-carboxyphenylglycine (CPG) and (RS)-α-methyl-4-carboxyphenylglycine (MCPG). Eur.J.Pharmacol.Mol.Pharmacol.Sect. 244 195
If you know of a relevant reference for (RS)-MCPG disodium salt, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: (RS)-MCPG disodium salt, (RS)-MCPG disodium salt supplier, Non-Selective, mGlur, antagonists, Group, I, II, Receptors, mGlu2, mGlu3, mGluR2, mGluR3, Glutamate, Metabotropic, mGlu1, mGlu5, mGluR1, mGluR5, 1303994-09-3, Non-selective, mGlu, 3696, Tocris Bioscience
2 Citations for (RS)-MCPG disodium salt
Citations are publications that use Tocris products. Selected citations for (RS)-MCPG disodium salt include:
Hajime et al (2022) Activation of Glutamate Transport Increases Arteriole Diameter in v ivo: Implications for Neurovascular Coupling. Front Cell Neurosci 16 831061 PMID: 35308116
David D et al (2019) Distinct Modes of Presynaptic Inhibition of Cutaneous Afferents and Their Functions in Behavior. Neuron 102 420-434.e8 PMID: 30826183
Do you know of a great paper that uses (RS)-MCPG disodium salt from Tocris? Please let us know.
Reviews for (RS)-MCPG disodium salt
Average Rating: 5 (Based on 1 Review.)
Have you used (RS)-MCPG disodium salt?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Filter by:
Suppression of mGluR action triggered by glutamate application.
By
Sergiy Sylantyev on 10/15/2020
Species: Human
Cell Line/Tissue: Stem cell - derived neurons
(RS)-MCPG disodium salt was in use to prevent contamination of NMDA-receptor – generated response to prolonged application of glutamate with (possible) impact from metabotropic glutamate receptors (mGluRs). APV, applied after glutamate, fully suppressed NMDA-receptor response, thus suggesting no input from mGluRs (see illustration). MCPG disodium salt works as expected; the effects and time interval for response development are same with those of (RS)-MCPG, but the salt is much easier soluble.
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Metabotropic Glutamate Receptors Scientific Review
Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.