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Discontinued Product
1220 has been discontinued.
View all Glutamate (Metabotropic) Group III Receptors products.
Description: Potent and selective mGlu8 agonist
Chemical Name: (RS)-4-Phosphonophenylglycine
Biological Activity for (RS)-PPG
(RS)-PPG is a potent and selective group III metabotropic glutamate receptor agonist, with approximately 25-fold preference for hmGlu8; anticonvulsant and neuroprotective in vivo.
Technical Data for (RS)-PPG
| M. Wt | 231.14 |
| Formula | C8H10NO5P |
| Storage | Store at RT |
| CAS Number | 120667-15-4 |
| PubChem ID | 4545574 |
| InChI Key | JRQRKFDFHAPMGQ-UHFFFAOYSA-N |
| Smiles | NC(C(O)=O)C1=CC=C(P(O)(O)=O)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for (RS)-PPG
References for (RS)-PPG
References are publications that support the biological activity of the product.
Bigge et al (1989) Exploration of phenyl-spaced 2-amino-(5,9)-phosphonoalkanoic acids as competitive N-MthD.-aspartic acid antagonists. J.Med.Chem. 32 1580 PMID: 2544728
Gasparini et al (1999) (R,S)-4-Phosphonophenylglycine, a potent and selective group III metabotropic glutamate receptor agonist, is anticonvulsive and neuroprotective in vivo. J.Pharmacol.Exp.Ther. 289 1678 PMID: 10336568
Flor et al (1998) Neuroprotection in vitro and in vivo by (R,S)-PPG, a potent and selective group III metabotropic glutamate receptor agonist. Soc.Neurosci.Abstr. 24 431.11
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Keywords: (RS)-PPG, (RS)-PPG supplier, Potent, selective, mGlu8, mGluR8, agonist, Group, III, Receptors, Glutamate, Metabotropic, (Metabotropic), 1220, Tocris Bioscience
1 Citation for (RS)-PPG
Citations are publications that use Tocris products. Selected citations for (RS)-PPG include:
Kammermeier (2015) Constitutive activity of metabotropic glutamate receptor 7. Neuropharmacology 16 17 PMID: 25881041
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Metabotropic Glutamate Receptors Scientific Review
Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.
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