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Submit ReviewRuBi-Nicotine
Description: Caged nicotine; rapidly excitable by visible light
Chemical Name: Bis(2,2'-bipyridine-N,N')bis(S-nicotine-N1) ruthenium(2+) dichloride
Biological Activity for RuBi-Nicotine
RuBi-Nicotine is a ruthenium-bisbipyridine-caged nicotine, excitable by irradiation with visible light. Undergoes rapid photolysis to release nicotine (< 20 ns); exhibits a high quantum yield. Induces action potential propagation in Retzius neurons of leech ganglia with no detectable toxicity at a concentration of 1 mM.
Licensing Information
Sold under licence from Columbia University
Technical Data for RuBi-Nicotine
| M. Wt | 808.81 |
| Formula | C40H44Cl2N8Ru |
| Storage | Store at -20°C |
| CAS Number | 1256362-30-7 |
| PubChem ID | 90488888 |
| InChI Key | DRYNYXIOLIUZSG-ZPFSJBFKSA-L |
| Smiles | [Cl-].[Cl-].[Ru++].C1=CN=C(C=C1)C1=CC=CC=N1.C1=CC=C(N=C1)C1=CC=CC=N1.[H][C@]1(CCCN1C)C1=CC=CN=C1.[H][C@]1(CCCN1C)C1=CC=CN=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for RuBi-Nicotine
References for RuBi-Nicotine
References are publications that support the biological activity of the product.
Filevich et al (2010) A caged nicotine with nanosecond range kinetics and visible light sensitivity. J.Inorg.Biochem. 104 1248 PMID: 20825994
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Keywords: RuBi-Nicotine, RuBi-Nicotine supplier, RuBiNicotine, caged, compounds, nicotinics, cholinergics, acetylcholine, receptors, nAChRs, agonist, excitatory, Nicotinic, Receptors, (Non-selective), Caged, Compounds, 3855, Tocris Bioscience
1 Citation for RuBi-Nicotine
Citations are publications that use Tocris products. Selected citations for RuBi-Nicotine include:
Lorna W et al (2022) Axonal α7* nicotinic acetylcholine receptors modulate glutamatergic signaling and synaptic vesicle organization in ventral hippocampal projections. Front Neural Circuits 16 978837 PMID: 36213206
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