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Submit ReviewRVD-Hpα
Description: Selective CB1 agonist; also CB2 PAM
Alternative Names: Pepcan-12
Biological Activity for RVD-Hpα
RVD-Hpα is a N-terminally extended form of human hemopressin that acts as a selective CB1 receptor agonist. Increases intracellular Ca2+ levels in cells expressing CB1 receptors in vitro. Also high affinity CB2 positive allosteric modulator (Ki = 50 nM).
Technical Data for RVD-Hpα
| M. Wt | 1424.66 |
| Formula | C65H105N19O17 |
| Sequence | RVDPVNFKLLSH |
| Storage | Store at -20°C |
| CAS Number | 1193362-76-3 |
| PubChem ID | 90488874 |
| InChI Key | CSDQEWILNKOWRN-WSDCEOHFSA-N |
| Smiles | [H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CNC=N1)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for RVD-Hpα
References for RVD-Hpα
References are publications that support the biological activity of the product.
Gomes et al (2009) Novel endogenous peptide agonists of cannabinoid receptors. FASEB J. 23 3020 PMID: 19380512
Khurana et al (2017) Modulation of CB1 cannabinoid receptor by allosteric ligands: Pharmacology and therapeutic opportunities. Neuropharmacology 124 3 PMID: 28527758
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Citations for RVD-Hpα
Citations are publications that use Tocris products.
Currently there are no citations for RVD-Hpα.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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