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Submit ReviewRWJ 52353
Discontinued Product
3935 has been discontinued.
View all Adrenergic α<sub>2</sub> Receptors products.
Description: α2D agonist
Chemical Name: 5-(6,7-Dihydrobenzo[b]thien-4-yl-1H-imidazole hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for RWJ 52353
RWJ 52353 is a agonist of the α2D adrenergic receptor (Ki values are 1.5, 254, 443 and 621 nM for α2D, α2A, α1 and α2B adrenergic receptors respectively).
Technical Data for RWJ 52353
| M. Wt | 202.28 |
| Formula | C11H10N2S |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 245744-10-9 |
| PubChem ID | 71752148 |
| InChI Key | LIHWQUZNTRDJFW-UHFFFAOYSA-N |
| Smiles | C1(SC=C2)=C2C(C3=CN=CN3)=CCC1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for RWJ 52353
References for RWJ 52353
References are publications that support the biological activity of the product.
Ross et al (2000) α2 adrenoceptor agonists as potential analgesic agents. 2. Discovery of 4-(4-imidazo)-1,3-dimethyl-6,7-dihydrothianaphthene as a high-affinity ligand for the α2D adrenergic receptor. J.Med.Chem. 43 765 PMID: 10753480
Amphoux et al (2010) Inhibitory and facilitatory actions of isocyanine derivatives at human and rat organic cation transporters 1, 2 and 3: a comparison to human α1- and α2-adrenoceptor subtypes. Eur.J.Pharmacol. 634 1 PMID: 20170649
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Keywords: RWJ 52353, RWJ 52353 supplier, RWJ52353, agonists, alpha2D, a2d, α2d, adrenergic, receptors, adrenoceptors, Adrenergic, Alpha-2, Receptors, 3935, Tocris Bioscience
Citations for RWJ 52353
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Currently there are no citations for RWJ 52353.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.