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Submit ReviewS 32826
Description: Potent autotaxin inhibitor
Chemical Name: [4-(Tetradecanoylamino)benzyl]phosphonic acid disodium salt
Purity: ≥98% (HPLC)
Biological Activity for S 32826
S 32826 is an inhibitor of autotaxin (IC50 = 9 nM). Displays similar inhibitory effects at all three autotaxin isoforms (α, β and γ). Exhibits no affinity for lysophosphatidic acid receptor 1 (LPA1) at concentrations up to 10 μM. Inhibits LPA release from adipocytes (IC50 = 90 nM).
Technical Data for S 32826
| M. Wt | 441.45 |
| Formula | C21H34NO4PNa2 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1103672-43-0 |
| PubChem ID | 71311878 |
| InChI Key | DGRFALMFDGBLCP-UHFFFAOYSA-L |
| Smiles | [Na+].[Na+].CCCCCCCCCCCCCC(=O)NC1=CC=C(CP([O-])([O-])=O)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for S 32826
References for S 32826
References are publications that support the biological activity of the product.
Ferry et al (2008) S32826, a nanomolar inhibitor of autotaxin: discovery, synthesis and applications as a pharmacological tool. J.Pharmacol.Exp.Ther. 327 809 PMID: 18755937
Li et al (2011) Autotaxin is induced by TSA through HDAC3 and HDAC7 inhibition and antagonizes the TSA-induced cell apoptosis. Mol.Cancer 10 18 PMID: 21314984
Gaetano et al (2009) Inhibition of autotaxin production or activity blocks lysophosphatiylcholine-induced migration of human breast cancer and melanoma cells. Mol.Carcinogenesis 48 801
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Keywords: S 32826, S 32826 supplier, S32826, autotaxin, atx, inhibits, inhibitors, LPA, lysophosphatidic, acid, lipids, enpp2, lysophospholipases, phospholipases, Autotaxin, 3404, Tocris Bioscience
Citations for S 32826
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