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Submit Review(S)-(-)-Carbidopa
Description: Aromatic L-amino acid decarboxylase inhibitor
Chemical Name: (S)-α-Hydrazino-α-methyl-β-(3,4-dihydroxyphenyl)propionic acid
Purity: ≥99% (HPLC)
Biological Activity for (S)-(-)-Carbidopa
(S)-(-)-Carbidopa is a peripheral decarboxylase inhibitor, used in combination with levodopa for treatment of Parkinsonism.
Technical Data for (S)-(-)-Carbidopa
| M. Wt | 226.23 |
| Formula | C10H14N2O4 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 28860-95-9 |
| PubChem ID | 34359 |
| InChI Key | TZFNLOMSOLWIDK-JTQLQIEISA-N |
| Smiles | OC1=C(O)C=CC(C[C@@](NN)(C)C(O)=O)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for (S)-(-)-Carbidopa
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 4.52 | 20 |
Preparing Stock Solutions for (S)-(-)-Carbidopa
The following data is based on the product molecular weight 226.23. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 22.1 mL | 110.51 mL | 221.01 mL |
| 1 mM | 4.42 mL | 22.1 mL | 44.2 mL |
| 2 mM | 2.21 mL | 11.05 mL | 22.1 mL |
| 10 mM | 0.44 mL | 2.21 mL | 4.42 mL |
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Product Datasheets for (S)-(-)-Carbidopa
References for (S)-(-)-Carbidopa
References are publications that support the biological activity of the product.
Cheng et al (1992) Carbidopa inhibition of aromatic L-amino acid decarboxylase in rat brain capilliaries. FASEB J. 6 A1589
Kopfhammer et al (1985) L-Dopa infusion experiments in combination with the L-dopa decarboxylase inhibitors benserazide and carb. - L-dopa metabolism and neuroendocrinological effects. Pharmacopsychiatry 18 143
Merck Index 12 1843
If you know of a relevant reference for (S)-(-)-Carbidopa, please let us know.
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Keywords: (S)-(-)-Carbidopa, (S)-(-)-Carbidopa supplier, Aromatic, Lamino, acid, decarboxylase, inhibitors, inhibits, Decarboxylases, Dopaminergic-Related, 0455, Tocris Bioscience
Citations for (S)-(-)-Carbidopa
Citations are publications that use Tocris products.
Currently there are no citations for (S)-(-)-Carbidopa. Do you know of a great paper that uses (S)-(-)-Carbidopa from Tocris? Please let us know.
Reviews for (S)-(-)-Carbidopa
Average Rating: 5 (Based on 1 Review.)
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Carbidopa was used to understand it's effect on brain DDC conversion of levodopa/L-DOPA to dopamine.
By
Provs Pantha on 08/16/2019
Species: Human
Carbidopa acts as a peripheral DDC inhibitor, and carbidopa was used to understand it's effect on brain DDC conversion of levodopa/L-DOPA to dopamine.
