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Submit Review(S)-(-)-HA-966
Description: NMDA antagonist/partial agonist
Chemical Name: (S)-(-)-3-Amino-1-hydroxypyrrolidin-2-one
Purity: ≥98% (HPLC)
Biological Activity for (S)-(-)-HA-966
(S)-(-)-HA-966 is an possesses potent sedative and ataxic action, probably through disruption of striatal dopaminergic mechanisms.
R-enantiomer also available.
Technical Data for (S)-(-)-HA-966
| M. Wt | 116.12 |
| Formula | C4H8N2O2 |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 111821-58-0 |
| PubChem ID | 183351 |
| InChI Key | HCKUBNLZMKAEIN-VKHMYHEASA-N |
| Smiles | N[C@H]1CCN(O)C1=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for (S)-(-)-HA-966
References for (S)-(-)-HA-966
References are publications that support the biological activity of the product.
Grobaski et al (1997) Responses of rat substantia nigra DA-containing neurones to (-)-HA-966 in vitro. Br.J.Pharmacol. 120 575 PMID: 9051293
Shepard and Lehmann (1992) (±)-1-Hydroxy-3-aminopyrrolidone-2 (HA-966) inhibits the activity of substantia nigra DA neurons through a non-N-MthD.-aspartate receptor mediated mechanism. J.Pharmacol.Exp.Ther. 261 387 PMID: 1578355
Singh et al (1990) Enantiomers of HA-966 (3-amino-1-hydroxypyrrolidin-2-one) exhibit distinct central nervous system effects: (+)-HA-966 is a selective glycine/N-MthD.-aspartate receptor antagonist, but (-)-HA966 is a potent γ-butyrolactone-like sedative. Proc.Natl.Acad.Sci.U.S.A. 87 347 PMID: 2153294
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Keywords: (S)-(-)-HA-966, (S)-(-)-HA-966 supplier, NMDA, antagonists, partial, agonists, Glutamate, Receptors, N-Methyl-D-Aspartate, iGlu, Ionotropic, 0282, Tocris Bioscience
Citations for (S)-(-)-HA-966
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Currently there are no citations for (S)-(-)-HA-966.
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