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Submit Review(S)-(+)-Niguldipine hydrochloride
Discontinued Product
1123 has been discontinued.
View all Adrenergic α<sub>1</sub> Receptors products.
Description: α1 antagonist, L-type Ca2+ channel blocker
Chemical Name: (S)-1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid, 3-(4,4-diphenyl-1-piperidinyl)propyl methyl ester hydrochloride
Biological Activity for (S)-(+)-Niguldipine hydrochloride
(S)-(+)-Niguldipine hydrochloride is a L-type Ca2+ channel blocker and α1A-adrenoceptor antagonist; more active enantiomer.
R-enantiomer also available.
Technical Data for (S)-(+)-Niguldipine hydrochloride
| M. Wt | 646.18 |
| Formula | C36H39N3O6.HCl |
| Storage | Desiccate at -20°C |
| CAS Number | 113145-69-0 |
| PubChem ID | 6419995 |
| InChI Key | JTQJFSQQHGPLOX-UHFFFAOYSA-N |
| Smiles | O=C(OC)C1=C(C)NC(C)=C(C(OCCCN3CCC(C4=CC=CC=C4)(C5=CC=CC=C5)CC3)=O)[C@H]1[C@]2=CC=CC([N+]([O-])=O)=C2.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for (S)-(+)-Niguldipine hydrochloride
References for (S)-(+)-Niguldipine hydrochloride
References are publications that support the biological activity of the product.
Boer et al (1989) (+)-Niguldipine binds with very high affinity to Ca2+ channels and to a subtype of alpha1-adrenoceptor. Eur.J.Pharmacol. 172 131 PMID: 2548881
Graziadei et al (1989) Stereoselective binding of niguldipine enantiomers to alpha1A-adrenoceptors labeled with [3H]5-methyl-urapidil. Eur.J.Pharmacol. 172 329 PMID: 2555206
Hollt et al (1992) Stereoisomers of calcium antagonists which differ markedly in their potencies as calcium blockers are equally effective in modulating drug transport by P-glycoprotein. Biochem.Pharmacol. 43 2601 PMID: 1352973
Wetzel et al (1995) Discovery of alpha1a-adrenergic receptor antagonists based on the L-type Ca2+ channel antagonist niguldipine. J.Med.Chem. 38 1579 PMID: 7752182
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Keywords: (S)-(+)-Niguldipine hydrochloride, (S)-(+)-Niguldipine hydrochloride supplier, α1-adrenoceptor, alpha1-adrenoceptor, a1-adrenoceptor, a1-adrenergic, α1-adrenergic, alpha1-adrenergic, antagonists, L-type, Ca2+, channel, blockers, Receptors, Calcium, CaV, Channels, voltage-gated, voltage-dependent, Adrenergic, Alpha-1, Cav1.x, 1123, Tocris Bioscience
Citations for (S)-(+)-Niguldipine hydrochloride
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Currently there are no citations for (S)-(+)-Niguldipine hydrochloride.
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Literature in this Area
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Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.