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(S)-PFI 2 hydrochloride

Cat. No. 5400 1 Citation Submit a Review Datasheet / COA / SDS
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Description: Negative control of (R)-PFI 2 hydrochloride (Cat. No. 4892)
Chemical Name: 8-Fluoro-1,2,3,4-tetrahydro-N-[(1S)-2-oxo-2-(1-pyrrolidinyl)-1-[[3-(trifluoromethyl)phenyl]methyl]ethyl]-6-isoquinolinesulfonamide hydrochloride
Purity: ≥97% (HPLC)
Datasheet
Citations (1)
Reviews
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for (S)-PFI 2 hydrochloride

(S)-PFI 2 hydrochloride is a negative control of (R)-PFI 2 hydrochloride. Exhibits 500-fold lower activity in a SETD7 enzymatic assay (IC50 = 1 μM) compared to the active enantiomer.

Active Analog also available.

Licensing Information

This compound is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the (R)-PFI 2 probe summary on the SGC website.

Technical Data for (S)-PFI 2 hydrochloride

M. Wt 535.98
Formula C23H25F4N3O3S.HCl
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 1627607-88-8
PubChem ID 91691132
InChI Key ZADKZNVAJGEFLC-BOXHHOBZSA-N
Smiles O=C(N4CCCC4)[C@H](CC3=CC=CC(C(F)(F)F)=C3)NS(C2=CC1=C(C(F)=C2)CNCC1)(=O)=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for (S)-PFI 2 hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 53.6 100
ethanol 10.72 20

Preparing Stock Solutions for (S)-PFI 2 hydrochloride

The following data is based on the product molecular weight 535.98. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.87 mL 9.33 mL 18.66 mL
5 mM 0.37 mL 1.87 mL 3.73 mL
10 mM 0.19 mL 0.93 mL 1.87 mL
50 mM 0.04 mL 0.19 mL 0.37 mL

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Product Datasheets for (S)-PFI 2 hydrochloride

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References for (S)-PFI 2 hydrochloride

References are publications that support the biological activity of the product.

Barsyte-Lovejoy et al (2014) (R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells. Proc.Natl.Acad.Sci.U S A 111 12853 PMID: 25136132

If you know of a relevant reference for (S)-PFI 2 hydrochloride, please let us know.

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1 Citation for (S)-PFI 2 hydrochloride

Citations are publications that use Tocris products. Selected citations for (S)-PFI 2 hydrochloride include:

Judson et al (2018) Inhibition of methyltransferase Setd7 allows in vitro expansion of myogenic stem cells with improved therapetic potential. Cell Stem Cell 22 177 PMID: 29395054

Do you know of a great paper that uses (S)-PFI 2 hydrochloride from Tocris? Please let us know.

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