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Description: Dual inhibitor of LAG3 interaction with both MHCII and FGL1
Chemical Name: N-[4-[2-[2,5-Dimethyl-1-(phenylmethyl)-1H-pyrrol-3-yl]-2-oxoethoxy]phenyl]-2-furancarboxamide
Purity: ≥98% (HPLC)
Biological Activity for SA-15-P
SA-15-P is a dual inhibitor of the interaction of lymphocyte activation gene 3 (LAG3) with both the major histocompatibility complex class II (MHCII) and fibrinogen-like protein 1 (FGL1) (IC50 values from TR-FRET assay are 4.2 μM and 6.5 μM respectively).
Technical Data for SA-15-P
| M. Wt | 428.49 |
| Formula | C26H24N2O4 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 852846-00-5 |
| PubChem ID | 4786555 |
| InChI Key | IYGLJCOGIQDUAE-UHFFFAOYSA-N |
| Smiles | O=C(C1=CC=CO1)NC2=CC=C(C=C2)OCC(C3=C(C)N(CC4=CC=CC=C4)C(C)=C3)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for SA-15-P
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 42.85 | 100 |
Preparing Stock Solutions for SA-15-P
The following data is based on the product molecular weight 428.49. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.33 mL | 11.67 mL | 23.34 mL |
| 5 mM | 0.47 mL | 2.33 mL | 4.67 mL |
| 10 mM | 0.23 mL | 1.17 mL | 2.33 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.47 mL |
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Product Datasheets for SA-15-P
References for SA-15-P
References are publications that support the biological activity of the product.
Abdel-Rahman et al (2023) Discovery of first-in-class small molecule inhibitors of lymphocyte activation gene 3 (LAG-3). ACS Med.Chem.Lett. 14 629 PMID: 37197466
If you know of a relevant reference for SA-15-P, please let us know.
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Keywords: SA-15-P, SA-15-P supplier, SA15P, LAG3, inhibitor, interaction, MHCII, major, histocompatibility, complex, fibrinogen, like, protein, 1, FGL1, lymphocyte, activation, gene, immune, checkpoint, Immune, Checkpoints, 8050, Tocris Bioscience
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