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Description: Potent FAAH inhibitor
Chemical Name: 4-[2-(4-Chlorophenyl)ethyl]-1-piperidinecarboxylic acid 2-(methylamino)-2-oxoethyl ester
Purity: ≥99% (HPLC)
Biological Activity for SA 57
SA 57 is a potent inhibitor of fatty acid amide hydrolase (FAAH) (IC50 <10 nM). Also inhibits MAGL at higher concentrations (IC50 values are 410 nM and 1.4 μM respectively). Inhibits both human and mouse FAAH enzymes. Exhibits inhibitory activity against FAAH, MAGL and ABHD6 in vivo.
Technical Data for SA 57
| M. Wt | 338.83 |
| Formula | C17H23ClN2O3 |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 1346169-63-8 |
| PubChem ID | 44589122 |
| InChI Key | JFSSVCSHPDLFCM-UHFFFAOYSA-N |
| Smiles | ClC(C=C2)=CC=C2CCC1CCN(C(OCC(NC)=O)=O)CC1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for SA 57
References for SA 57
References are publications that support the biological activity of the product.
Niphakis et al (2012) O-hydroxyacetamide carbamates as a highly potent and selective class of endocannabinoid hydrolase inhibitors. ACS Chem.Neurosci. 3 418 PMID: 22860211
Owens et al (2016) Discriminative stimulus properties of the endocannabinoid catabolic enzyme inhibitor SA-57 in mice. J.Pharmacol.Exp.Ther 358 306 PMID: 27307500
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Keywords: SA 57, SA 57 supplier, SA57, FAAH, fatty, acid, amide, hydrolase, inhibitors, inhibits, potent, Fatty, Acid, Amide, Hydrolase, (FAAH), Other, Cannabinoids, 4752, Tocris Bioscience
Citations for SA 57
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Currently there are no citations for SA 57.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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