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Submit ReviewSAH-EZH2
Description: EZH2/EDD interaction inhibitor; suppresses PCR2 complex function
Biological Activity for SAH-EZH2
SAH-EZH2 is an EZH2/EPP interaction inhibitor (Kd = 320 nM). Suppresses EZH2 expression and H3K27 trimethylation by PCR2 complex. Arrests proliferation and induces monocyte to macrophage differentiation of MLL-AF9 leukemia cell line.
Licensing Information
Sold under license from Dana-Farber Cancer Institute
Technical Data for SAH-EZH2
| M. Wt | 3432.05 |
| Formula | C155H256N48O40 |
| Sequence |
FSSNRXKILXRTQILNQEWKQRRIQPV (Modifications: Phe-1 = N-terminal Ac, X = (S)-2-(4-pentenyl)alanine, X-6 and X-10 stapled together with a double bond) |
| Storage | Store at -20°C |
| CAS Number | 1453222-26-8 |
| Smiles | [H][C@]([C@H](O)C)(C(N[C@H](C(N[C@@]([C@H](CC)C)(C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@]([C@H](CC)C)(C(N[C@H](C(N1CCC[C@H]1C(N[C@H](C(O)=O)C(C)C)=O)=O)CCC(N)=O)=O)[H])=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCC(N)=O)=O)CCCCN)=O)CC2=CNC3=CC=CC=C23)=O)CCC(O)=O)=O)CCC(N)=O)=O)CC(N)=O)=O)CC(C)C)=O)[H])=O)CCC(N)=O)=O)NC([C@@H](NC([C@@]4(CCC/C=C/CCC[C@](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(C)=O)CC5=CC=CC=C5)=O)CO)=O)CO)=O)CC(N)=O)=O)CCCNC(N)=N)=O)(C(N[C@H](C(N[C@@]([C@H](CC)C)(C(N[C@H](C(N4)=O)CC(C)C)=O)[H])=O)CCCCN)=O)C)C)=O)CCCNC(N)=N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for SAH-EZH2
References for SAH-EZH2
References are publications that support the biological activity of the product.
Kim et al (2013) Targeted disruption of the EZH2-EED complex inhibits EZH2-dependent cancer. Nat.Chem.Biol. 9 643 PMID: 23974116
Kim et al (2015) SWI/SNF-mutant cancers depend on catalytic and non-catalytic activity of EZH2. Nat.Med. 21 1491 PMID: 26552009
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Keywords: SAH-EZH2, SAH-EZH2 supplier, EZH2, lysine, methyltransferase, EPP, interaction, inhibitors, inhibits, stapled, peptide, PCR2, complex, methylation, Stapled, Peptides, 6708, Tocris Bioscience
Citations for SAH-EZH2
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Currently there are no citations for SAH-EZH2.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Epigenetics Scientific Review
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Epigenetics in Cancer Poster
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