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Submit ReviewSarafotoxin S6b
Description: Endothelin receptor agonist; non-selective
Biological Activity for Sarafotoxin S6b
Vasoconstrictor peptide; non-selective endothelin receptor agonist.
Technical Data for Sarafotoxin S6b
| M. Wt | 2564 |
| Formula | C110H159N27O34S5 |
| Sequence |
CSCKDMTDKECLYFCHQDVIW (Modifications: Disulfide bridge between: 1-15, 3-11) |
| Storage | Desiccate at -20°C |
| CAS Number | 116303-65-2 |
| PubChem ID | 71308726 |
| InChI Key | ZHRYDGYRZIWZPS-RAALVGGVSA-N |
| Smiles | [H]N[C@H]1CSSC[C@H](NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CC2=CC=C(O)C=C2)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@H](CO)NC1=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Sarafotoxin S6b
References for Sarafotoxin S6b
References are publications that support the biological activity of the product.
Aimoto et al (1990) Studies on the disulfide bridges of sarafotoxins. Chemical synthesis of sarafotoxin S6B and its homologue with different disulfide bridges. Biochem.Int. 21 1051 PMID: 2080919
Bax et al (1994) Different endothelin receptors involved in endothelin-1- and sarafotoxin S6B-induced contractions of the human isolated coronary artery. Br.J.Pharmacol. 113 1471 PMID: 7889304
Devadason and Henry (1997) Comparison of the contractile effects and binding kinetics of endothelin-1 and sarafotoxin S6b in rat isolated renal artery. Br.J.Pharmacol. 121 253 PMID: 9154335
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Keywords: Sarafotoxin S6b, Sarafotoxin S6b supplier, Endothelin, receptor, agonists, non-selective, Non-Selective, ET, Receptors, ETA, ETB, SarafotoxinS6b, Non-selective, 1174, Tocris Bioscience
Citations for Sarafotoxin S6b
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