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Submit ReviewSarcosine is an endogenous inhibitor of GlyT1 that displays antipsychotic activity. Potentiates the action of glycine on the NMDA glycine binding site.
M. Wt | 89.09 |
Formula | C3H7NO2 |
Storage | Store at RT |
CAS Number | 107-97-1 |
PubChem ID | 1088 |
InChI Key | FSYKKLYZXJSNPZ-UHFFFAOYSA-N |
Smiles | OC(CNC)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Tsai et al (2004) Glycine transporter I inhibitor, N-methylglycine (Sarcosine), added to antipsychotics for the treatment of schizophrenia. Biol.Psychiatry 55 452 PMID: 15023571
Singh and Singh (2011) Meta-analysis of the efficacy of adjunctive NMDA receptor modulators in chronic schizophrenia. CNS Drugs. 25 859 PMID: 21936588
Keywords: Sarcosine, Sarcosine supplier, GlyT1, inhibitors, inhibits, Glycine, Transporters, Monoamine, Neurotransmitter, 2975, Tocris Bioscience
Citations are publications that use Tocris products. Selected citations for Sarcosine include:
Yoshikawa et al (2012) Glycine transporter type 2 (GlyT2) inhibitor ameliorates bladder overactivity and nociceptive behavior in rats. Eur Urol 62 704 PMID: 22341128
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