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Submit ReviewSB 399885 hydrochloride
Description: Potent and selective 5-HT6 antagonist
Chemical Name: N-(3,5-Dichloro-2-methoxyphenyl)-4-methoxy-3-(1-piperazinyl)benzenesulfonamide hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for SB 399885 hydrochloride
SB 399885 hydrochloride is a potent, brain penetrant, orally active 5-HT6 antagonist. Displays > 200-fold selectivity for 5-HT6 over other 5-HT receptors (pKi values are 9.11, 8.81 and 9.02 for human recombinant, native rat and native human 5-HT6 receptors respectively).
Compound Libraries for SB 399885 hydrochloride
SB 399885 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for SB 399885 hydrochloride
| M. Wt | 482.81 |
| Formula | C18H21Cl2N3O4S.HCl |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 402713-81-9 |
| PubChem ID | 6918649 |
| InChI Key | ATKZKAYWARYLBW-UHFFFAOYSA-N |
| Smiles | Cl.ClC1=CC(Cl)=CC(NS(C2=CC(N3CCNCC3)=C(OC)C=C2)(=O)=O)=C1OC |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for SB 399885 hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 48.28 | 100 | |
| DMSO | 48.28 | 100 |
Preparing Stock Solutions for SB 399885 hydrochloride
The following data is based on the product molecular weight 482.81. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.07 mL | 10.36 mL | 20.71 mL |
| 5 mM | 0.41 mL | 2.07 mL | 4.14 mL |
| 10 mM | 0.21 mL | 1.04 mL | 2.07 mL |
| 50 mM | 0.04 mL | 0.21 mL | 0.41 mL |
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Product Datasheets for SB 399885 hydrochloride
References for SB 399885 hydrochloride
References are publications that support the biological activity of the product.
Wesolowska and Nikiforuk (2007) Effects of the brain-penetrant and selective 5-HT6 receptor antagonist SB-399885 in animal models of anxiety and depression. Neuropharmacology 52 1274 PMID: 17320917
Foley et al (2008) The selective 5-HT6 receptor antagonists SB-271046 and SB-399885 potentiate NCAM PSA immunolabeling of dentate granule cells, but not neurogenesis, in the hippocampal formation of mature Wistar rats. Neuropharmacology 54 1166 PMID: 18455201
Hirst et al (2006) SB-399885 is a potent, selective 5-HT6 receptor antagonist with cognitive enhancing properties in aged rat water maze and novel object recognition models. Eur.J.Pharm. 553 109 PMID: 1706979
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Keywords: SB 399885 hydrochloride, SB 399885 hydrochloride supplier, Potent, selective, 5-HT6, antagonists, Serotonin, Receptors, 5-Hydroxytryptamine, SB399885, hydrochloride, 3189, Tocris Bioscience
2 Citations for SB 399885 hydrochloride
Citations are publications that use Tocris products. Selected citations for SB 399885 hydrochloride include:
Garfield et al (2014) Distribution of cells responsive to 5-HT6 receptor antagonist-induced hypophagia. J Exp Med 266 201 PMID: 24566060
Nagata et al (2019) Blockade of multiple monoamines receptors reduce insulin secretion from pancreatic β-cells. Sci Rep 9 16438 PMID: 31712714
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
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Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.