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Submit ReviewSB 699551
Description: Selective 5-ht5a antagonist
Chemical Name: N-[2-(Dimethylamino)ethyl]-N-[[4'-[[(2-phenylethyl)amino]methyl][1,1'-biphenyl]-4-yl]methyl]cyclopentanepropanamide dihydrochloride
Purity: ≥99% (HPLC)
Biological Activity for SB 699551
SB 699551 is a selective 5-ht5a receptor antagonist (pKi values are 8.3, < 6.0, < 6.0, < 6.0, < 5.5 and < 5.5 for 5-ht5a, 5-HT1B/D, 5-HT2A, 5-HT2C, 5-HT1A and 5-HT7 receptors respectively).
Licensing Information
Sold for research purposes under agreement from GlaxoSmithKline
Technical Data for SB 699551
| M. Wt | 584.66 |
| Formula | C34H45N3O.2HCl |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 864741-95-7 |
| PubChem ID | 11983346 |
| InChI Key | QJMKBIHLMPTYTI-UHFFFAOYSA-N |
| Smiles | O=C(CCC4CCCC4)N(CCN(C)C)CC(C=C2)=CC=C2C1=CC=C(CNCCC3=CC=CC=C3)C=C1.Cl.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for SB 699551
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 14.62 | 25 | |
| ethanol | 5.85 | 10 |
Preparing Stock Solutions for SB 699551
The following data is based on the product molecular weight 584.66. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.25 mM | 6.84 mL | 34.21 mL | 68.42 mL |
| 1.25 mM | 1.37 mL | 6.84 mL | 13.68 mL |
| 2.5 mM | 0.68 mL | 3.42 mL | 6.84 mL |
| 12.5 mM | 0.14 mL | 0.68 mL | 1.37 mL |
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Product Datasheets for SB 699551
References for SB 699551
References are publications that support the biological activity of the product.
Thomas et al (2006) SB-69951-A (3-cyclopentyl-N-[2-(dimethylamino)ethyl]-N-[(4'-{[(2-phenylethyl)amino]methyl}-4-biphenylyl)methyl]propanamide dihydrochloride), a novel 5-ht5A receptor-selective antagonist, enhances 5-HT neuronal function: evidence for an auto Neuropharmacology 51 566 PMID: 16846620
Thomas (2006) 5-ht5A receptors as a therapeutic target. Pharmacol.Ther. 111 707 PMID: 16516972
Corbett et al (2005) Discovery of a potent and selective 5-ht5A receptor antagonist by high-throughput chemistry. Bioorg.Med.Chem.letts. 15 4014 PMID: 16002289
If you know of a relevant reference for SB 699551, please let us know.
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Citations for SB 699551
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.