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Description: HDAC1/3 inhibitor
Chemical Name: N,N'-Dihydroxyoctanediamide
Biological Activity for SBHA
SBHA is a histone deacetylase (HDAC) inhibitor (ID50 values are 0.25 and 0.3 μM for HDAC1 and HDAC3 respectively). Potentiates the cytostatic effects of 5-Fluorouracil (Cat. No. 3257) in colorectal cancer cells.
Technical Data for SBHA
| M. Wt | 204.22 |
| Formula | C8H16N2O4 |
| Storage | Store at +4°C |
| CAS Number | 38937-66-5 |
| PubChem ID | 5173 |
| InChI Key | IDQPVOFTURLJPT-UHFFFAOYSA-N |
| Smiles | O=C(CCCCCCC(NO)=O)NO |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for SBHA
References for SBHA
References are publications that support the biological activity of the product.
Zhang et al (2004) The histone deacetylase inhibitor suberic bishydroxamate regulates the expression of multiple apoptotic mediators and induces mitochondria-dependent apoptosis of melanoma cells. Mol.Cancer.Ther. 3 425 PMID: 15078986
Brinkmann et al (2001) Histone hyperacetylation induced by histone deacetylase inhibitors is not sufficient to cause growth inhibition in human dermal fibroblasts. J.Biol.Chem. 276 22491 PMID: 11304533
Richon et al (1998) A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases. Proc.Natl.Acad.Sci.U.S.A 95 3003 PMID: 9501205
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Keywords: SBHA, SBHA supplier, HDAC, inhibits, inhibitors, histone, deacetylases, induces, inducers, of, apoptosis, epigenetics, Class, I, HDACs, 3810, Tocris Bioscience
Citations for SBHA
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Currently there are no citations for SBHA.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Epigenetics Scientific Review
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.
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