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Submit ReviewSC 57461A
Discontinued Product
3107 has been discontinued.
View all Leukotriene A<sub>4</sub> Hydrolase products.
Description: Selective inhibitor of LTA4 hydrolase
Chemical Name: N-methyl-N-[3-[4-(phenylmethyl)phenoxy]propyl]-β-alanine hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for SC 57461A
SC 57461A is a potent and selective inhibitor of LTA4 hydrolase. Does not inhibit other enzymes of the arachidonic acid cascade including COX-1, COX-2, LTC4 synthase and 5-lipoxygenase. Potently inhibits LTB4 production in whole blood (IC50 = 49 nM). Orally active.
Licensing Information
Sold for research purposes under agreement from Pfizer Inc.
Technical Data for SC 57461A
| M. Wt | 363.88 |
| Formula | C20H25NO3.HCl |
| Storage | Desiccate at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 423169-68-0 |
| PubChem ID | 9820433 |
| InChI Key | SBBJJLDNKNNWFJ-UHFFFAOYSA-N |
| Smiles | CN(CCC(O)=O)CCCOC(C=C2)=CC=C2CC1=CC=CC=C1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for SC 57461A
References for SC 57461A
References are publications that support the biological activity of the product.
Penning et al (2002) Synthesis of potent leukotriene A4 hydrolase inhibitors. Identification of 3-[methyl[3-[4-(phenylmethyl)phenoxy]propyl]amino]propanoic acid. J.Med.Chem. 45 3482 PMID: 12139459
Askonas et al (2002) Pharmacological characterization of SC-57461A (3-[methyl[3-[4-(phenylmethyl)phenoxy]propyl]amino]propanoic acid HCl), a potent and selective inhibitor of leukotriene A4 hydrolase I: in vitro studies. J.Pharmacol.Exp.Ther. 300 577 PMID: 11805219
Kachur et al (2002) Pharmacological characterization of SC-57461A (3-[methyl[3-[4-(phenylmethyl)phenoxy]propyl]amino]propanoic acid HCl), a potent and selective inhibitor of leukotriene A4 hydrolase II: in vivo studies. J.Pharmacol.Exp.Ther. 300 583 PMID: 11805220
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Keywords: SC 57461A, SC 57461A supplier, Selective, inhibitors, inhibits, LTA4, hydrolases, SC57461A, Pfizer, Hydrolase, Aminopeptidases, 3107, Tocris Bioscience
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