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Submit ReviewSCH 221510
Description: Potent and selective NOP agonist
Chemical Name: 3-Endo-8-[bis(2-methylphenyl)methyl]-3-phenyl-8-azabicyclo[3.2.1]octan-3-ol
Purity: ≥99% (HPLC)
Biological Activity for SCH 221510
SCH 221510 is a potent and selective nociceptin opioid receptor (NOP) agonist (EC50 values are 12, 693, 683 and 8071 nM, and Ki values are 0.3, 65, 131 and 2854 nM at NOP, μ-, κ- and δ-opioid receptors respectively). Exhibits anxiolytic-like activity at doses that have no effect on overt behaviors such as locomotion in vivo. Orally active.
Compound Libraries for SCH 221510
SCH 221510 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for SCH 221510
| M. Wt | 397.55 |
| Formula | C28H31NO |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 322473-89-2 |
| PubChem ID | 9887077 |
| InChI Key | LOSJNRBXNQTUNT-UHFFFAOYSA-N |
| Smiles | OC1(C2=CC=CC=C2)CC3N(C(C5=CC=CC=C5C)C4=C(C)C=CC=C4)C(CC3)C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for SCH 221510
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 39.76 | 100 |
Preparing Stock Solutions for SCH 221510
The following data is based on the product molecular weight 397.55. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.52 mL | 12.58 mL | 25.15 mL |
| 5 mM | 0.5 mL | 2.52 mL | 5.03 mL |
| 10 mM | 0.25 mL | 1.26 mL | 2.52 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.5 mL |
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Product Datasheets for SCH 221510
References for SCH 221510
References are publications that support the biological activity of the product.
Varty et al (2008) The anxiolytic-like effects of the novel, orally active nociceptin opioid receptor agonist 8-[bis(2-methylphenyl)methyl]-3-phenyl-8-azabicyclo[3.2.1]octan-3-ol (SCH 221510). J.Pharmacol.Exp.Ther. 326 672 PMID: 18492950
Lambert (2008) The nociceptin/orphanin FQ receptor: a target with broad therapeutic potential. Nat.Rev.Drug Discov. 7 694 PMID: 18670432
Yang et al (2009) Identification of 3-substituted N-benzhydryl-nortropane analogs as nociceptin receptor ligands for the management of cough and anxiety. Bioorg.Med.Chem.Lett. 19 2482 PMID: 19332374
If you know of a relevant reference for SCH 221510, please let us know.
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Keywords: SCH 221510, SCH 221510 supplier, SCH221510, NOP, nociceptin, opioid, receptors, agonists, ORL1, Receptors, 3240, Tocris Bioscience
1 Citation for SCH 221510
Citations are publications that use Tocris products. Selected citations for SCH 221510 include:
Wu & Liu (2018) ORL1 activation mediates a novel ORL1 receptor agonist SCH221510 analgesia in neuropathic pain in rats. J Mol Neurosci 66 10 PMID: 30074175
Do you know of a great paper that uses SCH 221510 from Tocris? Please let us know.
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Literature in this Area
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.