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Description: Histone deacetylase inhibitor
Chemical Name: N-Hydroxy-1,3-dioxo-1H-benz[de]isoquinoline-2(3H)-hexanamide
Purity: ≥99% (HPLC)
Biological Activity for Scriptaid
Scriptaid is a novel histone deacetylase inhibitor. Produces > 100-fold increase in histone acetylation and displays relatively low toxicity.
Technical Data for Scriptaid
| M. Wt | 326.35 |
| Formula | C18H18N2O4 |
| Storage | Desiccate at -20°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 287383-59-9 |
| PubChem ID | 5186 |
| InChI Key | JTDYUFSDZATMKU-UHFFFAOYSA-N |
| Smiles | ONC(=O)CCCCCN1C(=O)C2=CC=CC3=CC=CC(C1=O)=C23 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Scriptaid
References for Scriptaid
References are publications that support the biological activity of the product.
Su et al (2000) A novel histone deacetylase inhibitor identified by high-throughput transcriptional screening of a compound library. Cancer Res. 60 3137 PMID: 10866300
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Keywords: Scriptaid, Scriptaid supplier, Histone, deacetylases, inhibitors, inhibits, HDAC, epigenetics, Non-selective, HDACs, Non-Selective, 2421, Tocris Bioscience
2 Citations for Scriptaid
Citations are publications that use Tocris products. Selected citations for Scriptaid include:
Sharma et al (2010) HDAC inhibitor, scriptaid, induces glioma cell apoptosis through JNK activation and inhibits telomerase activity. J Cell Mol Med 14 2151 PMID: 19583803
Kim (2018) Suppression of TGFβ-mediated conversion of endothelial cells and fibroblasts into cancer associated (myo)fibroblasts via HDAC inhibition. Br J Cancer 118 1359 PMID: 29695769
Reviews for Scriptaid
Average Rating: 5 (Based on 1 Review.)
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TGF beta high responder treated with 2 μM Scriptaid (HDAC 1/3/8 inhibitor) for 48 h. Cell lysates were analysed by western blot..
By
Anonymous on 11/15/2019
Assay Type: In Vivo
Species: Mouse
Cell Line/Tissue: C3-TAg tumour cell
TGF beta high responder treated with 2 μM Scriptaid (HDAC 1/3/8 inhibitor) for 48 h. Cell lysates were analysed by western blot.
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Epigenetics Scientific Review
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.
Rheumatoid Arthritis Poster
Rheumatoid arthritis (RA) is a chronic destructive inflammatory autoimmune disease that results from a breakdown in immune tolerance, for reasons that are as yet unknown. This poster summarizes the pathology of RA and the inflammatory processes involved, as well as describing some of the epigenetic modifications associated with the disease and the potential for targeting these changes in the discovery of new treatments.