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Submit ReviewSDZ 21009
Discontinued Product
1516 has been discontinued.
View all Non-selective Adrenergic β Receptors products.
Description: β-adrenoceptor antagonist; also 5-HT1A and 5-HT1B antagonist
Chemical Name: 4-[3-[(1,1-Dimethylethyl)amino]-2-hydroxypropoxy]-1H-indole-2-carboxylic acid, 1-methylethyl ester
Biological Activity for SDZ 21009
SDZ 21009 is an β-adrenoceptor and 5-HT1A/1B receptor antagonist. pKB/pA2 values are 8.3 and 8.0 for 5-HT1A and 5-HT1B receptors respectively. Centrally active following systemic administration in vivo.
Technical Data for SDZ 21009
| M. Wt | 348.44 |
| Formula | C19H28N2O4 |
| Storage | Store at RT |
| CAS Number | 39731-05-0 |
| PubChem ID | 193949 |
| InChI Key | SJYFDORQYYEJLB-UHFFFAOYSA-N |
| Smiles | CC(C)OC(=O)C1=CC2=C(OCC(O)CNC(C)(C)C)C=CC=C2N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for SDZ 21009
References for SDZ 21009
References are publications that support the biological activity of the product.
Chojnacka-Wojcik and Przegalinski (1991) Evidence for the involvement of 5-HT1A receptors in the anticonflict effect of ipsapirone in rats. Neuropharmacology 30 703 PMID: 1681448
Hoyer et al (1994) VII International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol.Rev. 46 157 PMID: 7938165
Engel et al (1986) Identity of inhibitory presynaptic 5-hydroxytryptamine (5-HT) autoreceptors in the rat brain cortex with 5-HT1B binding sites. Naunyn-Schmied.Arch.Pharmacol. 332 1
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Keywords: SDZ 21009, SDZ 21009 supplier, β-adrenoceptor, beta-adrenoceptor, b-adrenoceptor, antagonists, 5-HT1A/1B, β-adrenergic, beta-adrenergic, b-adrenergic, Receptors, Non-Selective, Serotonin, SDZ21009, Non-selective, Adrenergic, Beta, 5-HT1A, 5-HT1B, 1516, Tocris Bioscience
Citations for SDZ 21009
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Currently there are no citations for SDZ 21009.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.