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Submit ReviewSertraline hydrochloride
Description: 5-HT reuptake inhibitor
Chemical Name: (1S,4S)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthalenamine hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for Sertraline hydrochloride
Sertraline is a potent and selective serotonin (5-HT) reuptake inhibitor (SSRI) that is an orally active antidepressant. Sertraline also decreases ergosterol biosynthesis and exhibits antifungal activity against Candida auris in vitro. Sertraline acts as an inhibitor of SHMT(serine hydroxymethyltransferase), inhibiting serine/glycine synthesis and proliferation of serine/glycine synthesis-dependent breast cancer cell lines in vitro and in vivo.
Compound Libraries for Sertraline hydrochloride
Sertraline hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for Sertraline hydrochloride
| M. Wt | 342.69 |
| Formula | C17H17Cl2N.HCl |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 79559-97-0 |
| PubChem ID | 63009 |
| InChI Key | BLFQGGGGFNSJKA-XHXSRVRCSA-N |
| Smiles | ClC(C(Cl)=C3)=CC=[C@@]3[C@H]2C1=CC=CC=C1[C@@H](NC)CC2.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Sertraline hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 34.26 | 100 | |
| ethanol | 17.13 | 50 |
Preparing Stock Solutions for Sertraline hydrochloride
The following data is based on the product molecular weight 342.69. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.92 mL | 14.59 mL | 29.18 mL |
| 5 mM | 0.58 mL | 2.92 mL | 5.84 mL |
| 10 mM | 0.29 mL | 1.46 mL | 2.92 mL |
| 50 mM | 0.06 mL | 0.29 mL | 0.58 mL |
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Product Datasheets for Sertraline hydrochloride
References for Sertraline hydrochloride
References are publications that support the biological activity of the product.
Koe et al (1983) Sertraline, 1S,4S-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthylamine, a new uptake inhibitor with selectivity for serotonin. J.Pharmacol.Exp.Ther. 226 686 PMID: 6310078
Heym and Koe (1988) Pharmacology of sertraline: a review. J.Clin.Psychiatry 49 40 PMID: 3045112
Doogan and Caillard (1988) Sertraline: a new antidepressant. J.Clin.Psychiatry. 49 46 PMID: 2842321
Gowri et al (2020) Sertraline as a promising antifungal agent: inhibition of growth and biofilm of Candida auris with special focus on the mechanism of action in vitro. J.Appl.Microbiol. 128 426 PMID: 31621139
Geeraerts et al (2021) Repurposing the antidepressant Sertraline as SHMT inhibitor to suppress serine/glycine synthesis-addicted breast tumor growth. Mol.Cancer Ther. 20 50 PMID: 33203732
If you know of a relevant reference for Sertraline hydrochloride, please let us know.
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Keywords: Sertraline hydrochloride, Sertraline hydrochloride supplier, 5-HT, reuptake, inhibitors, inhibits, Serotonin, Transporters, SERT, 5-Hydroxytryptamine, Monoamine, Neurotransmitter, Pfizer, ssri, 5HTT, SLC6A4, SHMT, serine, hydroxymethyltransferase, antifungal, Other, Transferases, Antifungals, 2395, Tocris Bioscience
3 Citations for Sertraline hydrochloride
Citations are publications that use Tocris products. Selected citations for Sertraline hydrochloride include:
Pai et al (2015) Endogenous gradients of resting potential instructively pattern embryonic neural tissue via Notch signaling and regulation of proliferation. J Neurosci 35 4366 PMID: 25762681
Hooper et al (2016) Selective serotonin reuptake inhibitor exposure constricts the mouse ductus arteriosus in utero. Am J Physiol Heart Circ Physiol 311 H572 PMID: 27371685
Lyons et al (2016) Serotonin and Antidepressant SSRIs Inhibit Rat Neuroendocrine DA Neurons: Parallel Actions in the Lactotrophic Axis The journal of Neuroscience 36 7392 PMID: 27413150
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.