Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewSilodosin
Description: Selective α1A antagonist
Chemical Name: 2,3-Dihydro-1-(3-hydroxypropyl)-5-[(2R)-2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]-1H-indole-7-carboxamide
Purity: ≥98% (HPLC)
Biological Activity for Silodosin
Silodosin is a selective α1A adrenoceptor antagonist (Ki = 0.036 nM). Displays >55 fold selectivity for α1A over α1B and α1D. Inhibits norepinephrine-induced [Ca2+]I increase in α1A expressing CHO cells (IC50 = 0.32 nM). Inhibits norepinephrine-induced contraction of isolated human prostate tissue.
Compound Libraries for Silodosin
Silodosin is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.
Technical Data for Silodosin
| M. Wt | 495.53 |
| Formula | C25H32F3N3O4 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 160970-54-7 |
| PubChem ID | 5312125 |
| InChI Key | PNCPYILNMDWPEY-QGZVFWFLSA-N |
| Smiles | C[C@@H](NCCOC1=C(C=CC=C1)OCC(F)(F)F)CC2=CC(C(N)=O)=C3N(CCC3=C2)CCCO |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Silodosin
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 49.55 | 100 | |
| ethanol | 49.55 | 100 |
Preparing Stock Solutions for Silodosin
The following data is based on the product molecular weight 495.53. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.02 mL | 10.09 mL | 20.18 mL |
| 5 mM | 0.4 mL | 2.02 mL | 4.04 mL |
| 10 mM | 0.2 mL | 1.01 mL | 2.02 mL |
| 50 mM | 0.04 mL | 0.2 mL | 0.4 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets for Silodosin
References for Silodosin
References are publications that support the biological activity of the product.
Shibata et al (1995) KMD-3213, a novel, potent, alpha 1a-adrenoceptor-selective antagonist: characterization using recombinant human alpha 1-adrenoceptors and native tissues. Mol.Pharmacol. 48 250 PMID: 7651358
Moriyama et al (1997) KMD-3213, a novel alpha1A-adrenoceptor antagonist, potently inhibits the functional alpha1-adrenoceptor in human prostate. Eur.J.Pharmacol. 331 39 PMID: 9274928
If you know of a relevant reference for Silodosin, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Silodosin, Silodosin supplier, alpha, 1a, adrenoceptor, adrenergic, receptor, antagonists, antagonism, KMD-3213, Adrenergic, Alpha-1, Receptors, 6663, Tocris Bioscience
1 Citation for Silodosin
Citations are publications that use Tocris products. Selected citations for Silodosin include:
Wen Cheng et al (2022) A common variant in 11q23.3 associated with hyperlipidemia is mediated by the binding and regulation of GATA4. NPJ Genom Med 7 4 PMID: 35046404
Do you know of a great paper that uses Silodosin from Tocris? Please let us know.
Reviews for Silodosin
There are currently no reviews for this product. Be the first to review Silodosin and earn rewards!
Have you used Silodosin?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.