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SirReal 2

Cat. No. 5457 Submit a Review Datasheet / COA / SDS
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Description: Selective inhibitor of SIRT2
Chemical Name: 2-[(4,6-Dimethyl-2-pyrimidinyl)thio]-N-[5-(1-naphthalenylmethyl)-2-thiazolyl]acetamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for SirReal 2

SirReal 2 is a selective SIRT2 inhibitor (IC50 = 140 nM). Has minimal effect on SIRT1 and SIRT3-6. Increases α-tubulin acetylation levels in HeLa cells.

Compound Libraries for SirReal 2

SirReal 2 is also offered as part of the Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for SirReal 2

M. Wt 420.55
Formula C22H20N4OS2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 709002-46-0
PubChem ID 1096292
InChI Key MENNDDDTIIZDDN-UHFFFAOYSA-N
Smiles CC1=CC(C)=NC(SCC(NC2=NC=C(CC3=CC=CC4=C3C=CC=C4)S2)=O)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SirReal 2

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 42.05 100

Preparing Stock Solutions for SirReal 2

The following data is based on the product molecular weight 420.55. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.38 mL 11.89 mL 23.78 mL
5 mM 0.48 mL 2.38 mL 4.76 mL
10 mM 0.24 mL 1.19 mL 2.38 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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References for SirReal 2

References are publications that support the biological activity of the product.

Rumpf et al (2015) Selective SIRT2 inhibition by ligand-induced rearrangement of the active site. Nat.Commun. 6 6263 PMID: 25672491

If you know of a relevant reference for SirReal 2, please let us know.

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Keywords: SirReal 2, SirReal 2 supplier, SirReal2, selective, SIRT2, inhibitors, inhibits, Sirtuin, Sir2-like, Family, Deacetylases, Class, III, HDACs, (Sirtuins), 5457, Tocris Bioscience

Citations for SirReal 2

Citations are publications that use Tocris products.

Currently there are no citations for SirReal 2. Do you know of a great paper that uses SirReal 2 from Tocris? Please let us know.

Reviews for SirReal 2

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Literature in this Area

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Rheumatoid Arthritis Poster

Rheumatoid Arthritis Poster

Rheumatoid arthritis (RA) is a chronic destructive inflammatory autoimmune disease that results from a breakdown in immune tolerance, for reasons that are as yet unknown. This poster summarizes the pathology of RA and the inflammatory processes involved, as well as describing some of the epigenetic modifications associated with the disease and the potential for targeting these changes in the discovery of new treatments.