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Description: Selective HDAC11 inhibitor
Chemical Name: N'-Hexadecylthiophene-2-carbohydrazide
Purity: ≥95% (HPLC)
Biological Activity for SIS17
SIS17 is a selective HDAC11 inhibitor (IC50 = 0.83 μM). Inhibits demyristoylation of serine hydroxymethyl transferase 2 with no detectable activity at other HDAC subtypes. Combination with Oxaliplatin (Cat. No. 2623) increases cytotoxicity to K562 cells; improves survival of Oxaliplatin-treated 769P cells. Cell permeable.
Technical Data for SIS17
| M. Wt | 366.61 |
| Formula | C21H38N2OS |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 2374313-54-7 |
| PubChem ID | 139035087 |
| InChI Key | HSHXDCVZWHOWCS-UHFFFAOYSA-N |
| Smiles | O=C(NNCCCCCCCCCCCCCCCC)C=1SC=CC1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for SIS17
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 3.67 | 10 |
Preparing Stock Solutions for SIS17
The following data is based on the product molecular weight 366.61. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 27.28 mL | 136.38 mL | 272.77 mL |
| 0.5 mM | 5.46 mL | 27.28 mL | 54.55 mL |
| 1 mM | 2.73 mL | 13.64 mL | 27.28 mL |
| 5 mM | 0.55 mL | 2.73 mL | 5.46 mL |
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Product Datasheets for SIS17
References for SIS17
References are publications that support the biological activity of the product.
Son et al (2019) Activity-guided design of HDAC11-specific inhibitors. ACS Chem.Biol. 14 1393 PMID: 31264832
Li et al (2022) A pan-cancer analysis identifies HDAC11 as an immunological and prognostic biomarker. FASEB J. 36 e22326 PMID: 35657209
If you know of a relevant reference for SIS17, please let us know.
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Keywords: SIS17, SIS17 supplier, SIS17, HDAC, HDAC11, inhibitors, inhibit, inhibits, selective, cytotoxicity, Class, IV, HDACs, 7969, Tocris Bioscience
Citations for SIS17
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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