Home / Product Type / PROTAC® Degraders & Targeted Protein Degradation / Protein Degraders / p38 Mitogen Activated Protein Kinase (MAPK) Degraders / SJFδ

SJFδ

Cat. No. 7267 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Potent and selective p38δ PROTAC®
Chemical Name: N-(3-Fluoro-4-((7-(2-(2-(2-(2-(((2S,4R)-4-hydroxy-1-((S)-3-methyl-2-(1-oxoisoindolin-2-yl)butanoyl)pyrrolidine-2-carboxamido)methyl)-5-(4-methylthiazol-5-yl)phenoxy)ethoxy)ethoxy)ethoxy)-6-methoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (2)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for SJFδ

SJFδ is a potent and selective PROTAC ® Degrader of p38δ (DC50 = 46.17 nM; Dmax = 99.41%). SJFδ comprises the multikinase inhibitor foretinib joined by a linker to a VHL ligand. Exhibits no significant degradation of p38α, β or γ. Selectively degrades p38δ in MDA-MB-231 cells.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Technical Data for SJFδ

M. Wt 1168.28
Formula C62H63F2N7O12S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2254609-23-7
PubChem ID 137628678
InChI Key LYUUIIZKBMBNQV-CHOFKVETSA-N
Smiles COC1=CC2=C(C=C1OCCOCCOCCOC1=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@H](C(C)C)N3CC4=CC=CC=C4C3=O)C=CC(=C1)C1=C(C)N=CS1)N=CC=C2OC1=C(F)C=C(NC(=O)C2(CC2)C(=O)NC2=CC=C(F)C=C2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SJFδ

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 58.41 50

Preparing Stock Solutions for SJFδ

The following data is based on the product molecular weight 1168.28. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 1.71 mL 8.56 mL 17.12 mL
2.5 mM 0.34 mL 1.71 mL 3.42 mL
5 mM 0.17 mL 0.86 mL 1.71 mL
25 mM 0.03 mL 0.17 mL 0.34 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References for SJFδ

References are publications that support the biological activity of the product.

Smith et al (2019) Differential PROTAC substrate specificity dictated by orientation of recruited E3 ligase. Nat.Commun. 10 131 PMID: 30631068

If you know of a relevant reference for SJFδ, please let us know.

View Related Products by Target

Keywords: SJFd, SJFd supplier, protac, active, degraders, degrades, selective, potent, von, Hippel, Lindau, VHL, E3, ligases, targeted, protein, degradation, TPD, protacs, MAPK, p38delta, p38d, p38δ, p38, Mitogen, Activated, Protein, Kinase, (MAPK), Degraders, 7267, Tocris Bioscience

Citations for SJFδ

Citations are publications that use Tocris products.

Currently there are no citations for SJFδ. Do you know of a great paper that uses SJFδ from Tocris? Please let us know.

Reviews for SJFδ

There are currently no reviews for this product. Be the first to review SJFδ and earn rewards!

Have you used SJFδ?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

TPD and Induced Proximity Research Product Guide

TPD and Induced Proximity Research Product Guide

This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research, including:

  • Active Degraders
  • TAG Degradation Platform
  • Degrader Building Blocks
  • Assays for Protein Degradation
  • Induced Proximity Tools
Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia