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Submit ReviewSKF 86466 hydrochloride
Description: Potent and selective α2 antagonist
Chemical Name: 6-Chloro-N-methyl-2,3,4,5-tetrahydro-1-H-3-benzazepine hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for SKF 86466 hydrochloride
SKF 86466 hydrochloride is a potent and selective α2 antagonist at pre- and post-junctional α2-adrenoceptors (Ki values are 13 and 17 nM respectively). Exhibits antihypertensive activity in a rat model.
Compound Libraries for SKF 86466 hydrochloride
SKF 86466 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for SKF 86466 hydrochloride
| M. Wt | 232.15 |
| Formula | C11H14ClN.HCl |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 86129-54-6 |
| PubChem ID | 10220250 |
| InChI Key | JKQKVNMNAIFCFS-UHFFFAOYSA-N |
| Smiles | CN2CCC1=CC=CC(Cl)=C1CC2.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for SKF 86466 hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 23.21 | 100 | |
| DMSO | 23.21 | 100 |
Preparing Stock Solutions for SKF 86466 hydrochloride
The following data is based on the product molecular weight 232.15. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.31 mL | 21.54 mL | 43.08 mL |
| 5 mM | 0.86 mL | 4.31 mL | 8.62 mL |
| 10 mM | 0.43 mL | 2.15 mL | 4.31 mL |
| 50 mM | 0.09 mL | 0.43 mL | 0.86 mL |
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Product Datasheets for SKF 86466 hydrochloride
References for SKF 86466 hydrochloride
References are publications that support the biological activity of the product.
Roesler et al (1986) Characterization of the antihypertensive activity of SK&F 86466, a selective alpha-2 antagonist, in the rat. J.Pharmacol.Exp.Ther. 236 1 PMID: 2867209
Schafers et al (1990) An evaluation of the alpha-adrenoceptor antagonism produced by SK&F 86466 in healthy normotensive males. Br.J.Clin.Pharmacol. 30 884 PMID: 1981137
Hieble et al (1985) Selective alpha-2 adrenoceptor blockade by SK&F 86466: in vitro characterization of receptor sensitivity. J.Pharmacol.Exp.Ther. 236 90 PMID: 2867217
If you know of a relevant reference for SKF 86466 hydrochloride, please let us know.
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1 Citation for SKF 86466 hydrochloride
Citations are publications that use Tocris products. Selected citations for SKF 86466 hydrochloride include:
Zeltner et al (2016) Capturing the biology of disease severity in a PSC-based model of familial dysautonomia. Nat Med 22 1421 PMID: 27841875
Do you know of a great paper that uses SKF 86466 hydrochloride from Tocris? Please let us know.
Reviews for SKF 86466 hydrochloride
Average Rating: 4 (Based on 1 Review.)
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Worked great and at a nice price..
By
Anonymous on 06/30/2020
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: Human PSC
Great for passaging hPSCs with dissociation into single cells with 10 μM.
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.