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Submit ReviewSLU-PP-332
Description: Potent pan-ERR agonist
Chemical Name: (E)-4-Hydroxy-N'-(naphthalen-2-ylmethylene)benzohydrazide
Purity: ≥98% (HPLC)
Biological Activity for SLU-PP-332
SLU-PP-332 is a potent and selective pan estrogen related receptor (ERR) agonist (EC50 values are 98 nM, 230 nM and 430 nM for ERRα, ERRβ and ERRγ respectively). In a mouse model of metabolic syndrome SLU-PP-332 increases energy expenditure and fatty acid oxidation, decreases fat mass, and improves insulin sensitivity. Also increases mitochondrial respiration in vitro.
Technical Data for SLU-PP-332
| M. Wt | 290.32 |
| Formula | C18H14N2O2 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 303760-60-3 |
| PubChem ID | 5404083 |
| InChI Key | RNZIMBFHRXYRLL-XDHOZWIPSA-N |
| Smiles | O=C(C1=CC=C(C=C1)O)N/N=C/C2=CC3=C(C=CC=C3)C=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for SLU-PP-332
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 29.03 | 100 |
Preparing Stock Solutions for SLU-PP-332
The following data is based on the product molecular weight 290.32. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.44 mL | 17.22 mL | 34.44 mL |
| 5 mM | 0.69 mL | 3.44 mL | 6.89 mL |
| 10 mM | 0.34 mL | 1.72 mL | 3.44 mL |
| 50 mM | 0.07 mL | 0.34 mL | 0.69 mL |
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Product Datasheets for SLU-PP-332
References for SLU-PP-332
References are publications that support the biological activity of the product.
Billon et al (2023) Synthetic ERRα/β/γ agonist induces an ERRα-dependent acute aerobic exercise response and enhances exercise capacity. ACS Chem.Biol. 18 756 PMID: 36988910
Billon et al (2024) A synthetic ERR agonist alleviates metabolic syndrome. J.Pharmacol.Exp.Ther. 388 232 PMID: 37739806
If you know of a relevant reference for SLU-PP-332, please let us know.
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Keywords: SLU-PP-332, SLU-PP-332 supplier, SLUPP332, ERR, estrogen, related, receptor, receptors, agonist, agonists, ERRalpha, beta, gamma, mitochondrial, respiration, metabolic, syndrome, obesity, insulin, sensitivity, Estrogen, and, Related, Receptors, 8112, Tocris Bioscience
Citations for SLU-PP-332
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