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SNIPER(ER)-87

Cat. No. 7120 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Potent and selective ERα Degrader (SNIPER)
Chemical Name: (2S)-N-[(1S)-1-Cyclohexyl-2-[(2S)-2-[4-[3-[[14-[4-[1-(4-hydroxyphenyl)-2-phenyl-1-buten-1-yl]phenoxy]-12-methyl-11-oxo-3,6,9-trioxa-12-azatetradec-1-yl]oxy]benzoyl]-2-thiazolyl]-1-pyrrolidinyl]-2-oxoethyl]-2-(methylamino)propanamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (2)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for SNIPER(ER)-87

SNIPER(ER)-87 is a potent and selective estrogen receptor α (ERα) Degrader (Specific and Nongenetic IAP-dependent Protein Erasers or SNIPER) (DC50 = 3 nM). SNIPER(ER)-87 comprises the IAP binding ligand LCL 161 (Cat. No. 7178) joined by a linker to the estrogen-binding moiety 4-hydroxytamoxifen (Cat. No. 3412). The product decreases ERα levels in breast cancer cells in vitro and in mouse ovaries in vivo. SNIPER(ER)-87 also reduces ERα levels and inhibits tumor proliferation in breast cancer xenograft mouse models. ER alpha/NR3A1 antibodies validated for Simple Western™ (automated Western) instruments and Western Blot also available: Catalog # AF 5715 and MAB57151.

Technical Data for SNIPER(ER)-87

M. Wt 1044.32
Formula C59H73N5O10S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2222354-91-6
PubChem ID 155563319
InChI Key ILLYWIKUEZHTSD-RJFLEHBVSA-N
Smiles CC/C(C1=CC=CC=C1)=C(C2=CC=C(C=C2)OCCN(C(COCCOCCOCCOC3=CC(C(C4=CSC([C@@H]5CCCN5C([C@H](C6CCCCC6)NC([C@@H](NC)C)=O)=O)=N4)=O)=CC=C3)=O)C)\C7=CC=C(C=C7)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SNIPER(ER)-87

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 104.43 100

Preparing Stock Solutions for SNIPER(ER)-87

The following data is based on the product molecular weight 1044.32. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.96 mL 4.79 mL 9.58 mL
5 mM 0.19 mL 0.96 mL 1.92 mL
10 mM 0.1 mL 0.48 mL 0.96 mL
50 mM 0.02 mL 0.1 mL 0.19 mL

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Product Datasheets for SNIPER(ER)-87

Certificate of Analysis / Product Datasheet
Safety Datasheet

References for SNIPER(ER)-87

References are publications that support the biological activity of the product.

Ohoka et al (2017) In vivo knockdown of pathogenic proteins via specific and nongenetic inhibitor of apoptosis protein (IAP)-dependent protein erasers (SNIPERs). J.Biol.Chem. 292 4556 PMID: 28154167

If you know of a relevant reference for SNIPER(ER)-87, please let us know.

View Related Products by Target

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Citations for SNIPER(ER)-87

Citations are publications that use Tocris products.

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Literature in this Area

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TPD and Induced Proximity Research Product Guide

TPD and Induced Proximity Research Product Guide

This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research, including:

  • Active Degraders
  • TAG Degradation Platform
  • Degrader Building Blocks
  • Assays for Protein Degradation
  • Induced Proximity Tools
Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia