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Submit ReviewSodium butyrate
Description: Histone deacetylase inhibitor
Chemical Name: Butanoic acid sodium salt
Biological Activity for Sodium butyrate
Sodium butyrate is a histone deacetylase inhibitor (HDAC). Sodium butyrate restores contextual memory in a transgenic mouse model of Alzheimer's disease. In a transgenic mouse model of Huntington's disease, sodium butyrate ameliorates the neurodegenerative phenotype and extends survival. Sodium butyrate induces pancreatic progenitor formation, and directs the differentiation of mouse embryonic stem cells into hepatocytes when used in combination with the cytokine Activin A. Sodium butyrate also augments transcription factor stimulated iPSC generation. In hepatocellular carcinoma cells, Sodium butyrate downregulates expression of c-Myc resulting in decreased hexokinase 2 levels, inhibition of aerobic glycolysis and reduced cell growth.
Technical Data for Sodium butyrate
| M. Wt | 110.09 |
| Formula | C4H7NaO2 |
| Storage | Store at RT |
| CAS Number | 156-54-7 |
| PubChem ID | 5222465 |
| InChI Key | MFBOGIVSZKQAPD-UHFFFAOYSA-M |
| Smiles | [Na+].CCCC([O-])=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Sodium butyrate
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 11.01 | 100 |
Preparing Stock Solutions for Sodium butyrate
The following data is based on the product molecular weight 110.09. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 9.08 mL | 45.42 mL | 90.83 mL |
| 5 mM | 1.82 mL | 9.08 mL | 18.17 mL |
| 10 mM | 0.91 mL | 4.54 mL | 9.08 mL |
| 50 mM | 0.18 mL | 0.91 mL | 1.82 mL |
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Product Datasheets for Sodium butyrate
References for Sodium butyrate
References are publications that support the biological activity of the product.
Boffa et al (1978) Suppression of histone deacetylation in vivo and in vitro by sodium butyrate. J.Biol.Chem. 253 3364 PMID: 649576
Kilgore et al (2010) Inhibitors of class 1 histone deacetylases reverse contextual deficits in a mouse model of Alzheimer's disease. Neuropsychopharmacology 35 870 PMID: 20010553
Ren et al (2010) Effects of sodium butyrate on the differentiation of pancreatic and hepatic progenitor cells from mouse embryonic stem cells. J.Cell Biochem. 109 236 PMID: 19911386
Zhou et al (2010) Differentiation of mouse embryonic stem cells into hepatocytes induced by a combination of cytokines and sodium butyrate. J.Cell Biochem. 109 606 PMID: 20039312
Liang et al (2010) Butyrate promotes induced pluripotent stem cell generation. J.Biol.Chem. 285 25516 PMID: 20554530
Ferrante et al (2003) Histone deacetylase inhibition by sodium butyrate chemotherapy ameliorates the neurodegenerative phenotype in Huntington's disease mice. J.Neurosci. 23 9418 PMID: 14561870
Yu et al (2022) Sodium butyrate inhibits aerobic glycolysis of hepatocellular carcinoma cells via the c-myc/hexokinase 2 pathway. J.Cell.Mol.Med. 26 3031 PMID: 35429101
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Keywords: Sodium butyrate, Sodium butyrate supplier, Histone, deacetylase, inhibitors, inhibits, differentiation, progenitors, ESC, HDACs, stem, cells, epigenetics, Huntingtons, Alzheimers, neurodegeneration, Hepatocyte, Stem, Cells, Non-selective, Non-Selective, 3850, Tocris Bioscience
Citations for Sodium butyrate
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Reviews for Sodium butyrate
Average Rating: 5 (Based on 1 Review.)
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Acetylation assay.
By
Xiaoyu Zhang on 03/07/2024
Assay Type: In Vitro
Species: Human
5mM sodium butyrate added to in vitro acetylation assay buffer.Western Blot to detect histone acetylation. Lane1 is control. Lane 2 is treatment. It showed acetylation unregulated after treatment.
Literature in this Area
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