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Submit ReviewSodium Cromoglicate
Description: Promotes ESCs/iPSCs differentiation into pancreatic endocrine islet cells
Chemical Name: 5,5'-[(2-Hydroxy-1,3-propanediyl)bis(oxy)]bis[4-oxo-4H-1-benzopyran-2-carboxylic acid] disodium salt
Purity: ≥98% (HPLC)
Biological Activity for Sodium Cromoglicate
Sodium Cromoglicate is a promotes transformation ESCs/iPSCs into pancreatic endocrine islet cells. Facilitates differentiation from endocrine precursors. Also inhibits mast cell degranulation and histamine release. Antiasthmatic.
Technical Data for Sodium Cromoglicate
| M. Wt | 512.33 |
| Formula | C23H14Na2O11 |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 15826-37-6 |
| PubChem ID | 27503 |
| InChI Key | VLARUOGDXDTHEH-UHFFFAOYSA-L |
| Smiles | OC(COC1=C2C(C=C(C(O[Na])=O)OC2=CC=C1)=O)COC3=C4C(C=C(C(O[Na])=O)OC4=CC=C3)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Sodium Cromoglicate
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 25.62 | 50 |
Preparing Stock Solutions for Sodium Cromoglicate
The following data is based on the product molecular weight 512.33. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 3.9 mL | 19.52 mL | 39.04 mL |
| 2.5 mM | 0.78 mL | 3.9 mL | 7.81 mL |
| 5 mM | 0.39 mL | 1.95 mL | 3.9 mL |
| 25 mM | 0.08 mL | 0.39 mL | 0.78 mL |
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Product Datasheets for Sodium Cromoglicate
References for Sodium Cromoglicate
References are publications that support the biological activity of the product.
Orr and Cox (1969) Disodium Cromoglycate, an inhibitor of mast cell degranulation and histamine release induced by phospholipase A. Nature. 223 197 PMID: 4183038
Kondo et al (2017) Identification of a small molecule that facilitates the differentiation of human iPSCS/ESCs and mouse embryonic pancreatic explants into pancreatic endocrine cells. Diabetologia. 60 1454 PMID: 28534195
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Citations for Sodium Cromoglicate
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