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Description: Selective D4 antagonist
Alternative Names: PNU 101387,U 101387
Chemical Name: 4-[4-[2-[(1S)-3,4-Dihydro-1H-2-benzopyran-1-yl)ethyl]-1-piperazinyl]-benzenesulfonamide
Purity: ≥98% (HPLC)
Biological Activity for Sonepiprazole
Sonepiprazole is a selective, high affinity antagonist for the rat and human dopamine D4 receptor (Ki = 10 nM). Exhibits low affinity at other monoamine receptors (Ki > 2000 nM). Induces c-fos gene expression in medial prefrontal cortex in a similar manner to clozapine (Cat. No. 0444). Brain penetrant and orally available.
Licensing Information
Sold for research purposes under agreement from Pfizer Inc.
Technical Data for Sonepiprazole
| M. Wt | 401.52 |
| Formula | C21H27N3O3S |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 170858-33-0 |
| PubChem ID | 133079 |
| InChI Key | WNUQCGWXPNGORO-NRFANRHFSA-N |
| Smiles | O=S(C1=CC=C(N2CCN(CC[C@H]3C(C=CC=C4)=C4CCO3)CC2)C=C1)(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Sonepiprazole
References for Sonepiprazole
References are publications that support the biological activity of the product.
Merchant et al (1996) Pharmacological characterization of U-101387, a DA D4 receptor selective antagonist. J.Pharmacol.Exp.Ther. 279 1392 PMID: 8968364
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Keywords: Sonepiprazole, Sonepiprazole supplier, Sonepiprazole, selective, dopamine, antagonists, D4, receptors, dopaminergic, U101387, PNU101387, pfizer, PNU, 101387, U, Receptors, 4185, Tocris Bioscience
1 Citation for Sonepiprazole
Citations are publications that use Tocris products. Selected citations for Sonepiprazole include:
Nagata et al (2019) Blockade of multiple monoamines receptors reduce insulin secretion from pancreatic β-cells. Sci Rep 9 16438 PMID: 31712714
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Dopamine Receptors Scientific Review
Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.
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The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
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Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.