Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewSpermine tetrahydrochloride
Description: Modulator at polyamine site
Chemical Name: N,N'-Bis(3-aminopropyl)-1,4-butanediamine tetrahydrochloride
Biological Activity for Spermine tetrahydrochloride
Spermine tetrahydrochloride is a polyamine which produces a variety of modulatory effects on the NMDA receptor channel, acting through a specific site on the complex which can cause both agonist and antagonist effects.
Technical Data for Spermine tetrahydrochloride
| M. Wt | 348.19 |
| Formula | C10H26N4.4HCl |
| Storage | Desiccate at +4°C |
| CAS Number | 306-67-2 |
| PubChem ID | 9384 |
| InChI Key | XLDKUDAXZWHPFH-UHFFFAOYSA-N |
| Smiles | NCCCNCCCCNCCCN.Cl.Cl.Cl.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Spermine tetrahydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 34.82 | 100 |
Preparing Stock Solutions for Spermine tetrahydrochloride
The following data is based on the product molecular weight 348.19. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.87 mL | 14.36 mL | 28.72 mL |
| 5 mM | 0.57 mL | 2.87 mL | 5.74 mL |
| 10 mM | 0.29 mL | 1.44 mL | 2.87 mL |
| 50 mM | 0.06 mL | 0.29 mL | 0.57 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets for Spermine tetrahydrochloride
References for Spermine tetrahydrochloride
References are publications that support the biological activity of the product.
Benveniste and Mayer (1993) Multiple effects of spermine on N-MthD.-aspartic acid receptor responses of rat cultured hippocampal neurones. J.Physiol. 464 131 PMID: 8229795
Doyle and Shaw (1998) Investigation of the actions and antagonist activity of some polyamine analogues in vivo. Br.J.Pharmacol. 124 386 PMID: 9641557
Johnson (1996) Modulation of channel function by polyamines. TiPS 17 22 PMID: 8789355
Munir et al (1993) Polyamines modulate the neurotoxic effects of NMDA in vivo. Brain Res. 616 163 PMID: 8358608
If you know of a relevant reference for Spermine tetrahydrochloride, please let us know.
View Related Products by Target
Keywords: Spermine tetrahydrochloride, Spermine tetrahydrochloride supplier, modulators, polyamine, site, Glutamate, NMDA, Receptors, N-Methyl-D-Aspartate, iGlur, Ionotropic, 0958, Tocris Bioscience
8 Citations for Spermine tetrahydrochloride
Citations are publications that use Tocris products. Selected citations for Spermine tetrahydrochloride include:
Kim and Cho (2017) Encoding of Discriminative Fear Memory by Input-Specific LTP in the Amygdala. Neuron 95 1129 PMID: 28823727
Campioni et al (2009) Stress-induced changes in nucleus accumbens glutamate synaptic plasticity. J Neurosci 101 3192 PMID: 19357347
Soto et al (2009) Selective regulation of long-form calcium-permeable AMPA receptors by an atypical TARP, gamma-5. Nat Neurosci 12 277 PMID: 19234459
Quintana et al (2015) Acid-sensing ion channel 1a drives AMPA receptor plasticity following ischaemia and acidosis in hippocampal CA1 neurons. Proc Natl Acad Sci U S A 593 4373 PMID: 26174503
Biase et al (2011) NMDA receptor signaling in oligodendrocyte progenitors is not required for oligodendrogenesis and myelination. J Physiol 31 12650 PMID: 21880926
McGee et al (2015) Auxiliary Subunit GSG1L Acts to Suppress Calcium-Permeable AMPA Receptor Function. J Neurosci 35 16171 PMID: 26658868
Soto et al (2014) Molecular mechanisms contributing to TARP regulation of channel conductance and polyamine block of calcium-permeable AMPA receptors. J Neurosci 34 11673 PMID: 25164663
Zonouzi et al (2011) Bidirectional plasticity of calcium-permeable AMPA receptors in oligodendrocyte lineage cells. Nat Neurosci 14 1430 PMID: 21983683
Do you know of a great paper that uses Spermine tetrahydrochloride from Tocris? Please let us know.
Reviews for Spermine tetrahydrochloride
There are currently no reviews for this product. Be the first to review Spermine tetrahydrochloride and earn rewards!
Have you used Spermine tetrahydrochloride?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Huntington's Disease Research Product Guide
This product guide provides a background to Huntington's disease research and lists around 100 products for the study of:
- Somatic Instability
- Proteolysis and Inclusion Bodies
- Transcriptional Dysregulation
- Mitochondrial Dysfunction
- Nuclear-Cytoplasmic Transport Interference
- Excitotoxicity
- Stem Cells
Alzheimer's Disease Poster
Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Huntington's Disease Poster
Huntington's disease (HD) is a severe monogenic neurodegenerative disorder, which is characterized by the prevalent loss of GABAergic medium spiny neurons (MSN) in the striatum. This poster summarizes the effects of mutant huntingtin aggregation implicated in the pathology of HD, as well as highlighting the use of iPSCs for HD modeling.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.