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Submit ReviewSQ 22536
Description: Adenylyl cyclase inhibitor
Chemical Name: 9-(Tetrahydro-2-furanyl)-9H-purin-6-amine
Purity: ≥99% (HPLC)
Biological Activity for SQ 22536
SQ 22536 is an inhibitor of adenylyl cyclase (IC50 = 1.4 μM). Inhibits PGE1-stimulated increases in cAMP levels in intact human platelets. Cell permeable.
Compound Libraries for SQ 22536
SQ 22536 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for SQ 22536
| M. Wt | 205.22 |
| Formula | C9H11N5O |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 17318-31-9 |
| PubChem ID | 5270 |
| InChI Key | UKHMZCMKHPHFOT-UHFFFAOYSA-N |
| Smiles | NC1=C2N=CN(C3CCCO3)C2=NC=N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for SQ 22536
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 10.26 | 50 |
Preparing Stock Solutions for SQ 22536
The following data is based on the product molecular weight 205.22. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 9.75 mL | 48.73 mL | 97.46 mL |
| 2.5 mM | 1.95 mL | 9.75 mL | 19.49 mL |
| 5 mM | 0.97 mL | 4.87 mL | 9.75 mL |
| 25 mM | 0.19 mL | 0.97 mL | 1.95 mL |
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Product Datasheets for SQ 22536
References for SQ 22536
References are publications that support the biological activity of the product.
Fabbri et al (1991) Inhibition of adenylate cyclase of catfish and rat hepatocyte membranes by 9-(tetrahydro-2-furyl)adenine (SQ 22536). J.Enzyme Inhib. 5 87 PMID: 1669444
Harris et al (1979) Inhibition of adenylate cyclase in human blood platelets by 9-substituted adenine derivatives. J.Cyclic Nucleotide Res. 5 125 PMID: 221552
Hourani et al (2001) Role of cyclic nucleotides in vasodilations of the rat thoracic aorta induced by adenosine analogues. Br.J.Pharmacol. 133 833 PMID: 11454656
Mei et al (2014) Micropillar arrays as a high-throughput screening platform for therapeutics in multiple sclerosis. Nat.Methods. 20 954 PMID: 24997607
Madhavan et al (2018) Induction of myelinating oligodendrocytes in human cortical spheroids. Nat.Methods. PMID: 30046099
If you know of a relevant reference for SQ 22536, please let us know.
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Keywords: SQ 22536, SQ 22536 supplier, Adenylyl, cyclase, inhibitors, inhibits, Cyclases, adenylate, SQ22536, Cyclase, 1435, Tocris Bioscience
13 Citations for SQ 22536
Citations are publications that use Tocris products. Selected citations for SQ 22536 include:
Olesen et al (2016) The Vasopressin Type-2 Receptor and Prostaglandin Receptors EP2 and EP4 can Increase Aquaporin-2 Plasma Membrane Targeting Through a cAMP Independent Pathway. American Journal of Physiology - Renal Physiology 311 F935 PMID: 27558562
Meitzen et al (2011) β1-Adrenergic receptors activate two distinct signaling pathways in striatal neurons. J Neurochem 116 984 PMID: 21143600
Tang et al (2014) Lactate-mediated glia-neuronal signalling in the mammalian brain. Nat Commun 5 3284 PMID: 24518663
Morris et al (2009) C5a mediates peripheral blood neutrophil dysfunction in critically ill patients. Am J Respir Crit Care Med 180 19 PMID: 19324972
Costa et al (2018) Activation of Serotonin 5-HT7 Receptors Modulates Hippocampal Synaptic Plasticity by Stimulation of Adenylate Cyclases and Rescues Learning and Behavior in a Mouse Model of Fragile X Syndrome. Front Mol Neurosci 11 353 PMID: 30333723
Bhanu et al (2008) Inhibition of erythroblast growth and fetal hemoglobin production by ribofuranose-substituted adenosine derivatives. PLoS One 1782 504 PMID: 18586086
Luo (2017) β2-adrenoreceptor Inverse Agonist Down-regulates Muscarine Cholinergic Subtype-3 Receptor and Its Downstream Signal Pathways in Airway Smooth Muscle Cells in vitro. Scientific Reports 7 39905 PMID: 28051147
Wang et al (2015) Phosphorylation of STAT3 mediates the induction of cyclooxygenase-2 by cortisol in the human amnion at parturition. Sci.Signal. 8 PMID: 26508788
Du et al (2015) Adrenergic and serotonin receptors affect retinal superoxide generation in diabetic mice: relationship to capillary degeneration and permeability. FASEB J 29 2194 PMID: 25667222
Babu et al (2012) Genistein prevents hyperglycemia-induced monocyte adhesion to human aortic endothelial cells through preservation of the cAMP signaling pathway and ameliorates vascular inflammation in obese diabetic mice. J Nutr 142 724 PMID: 22399524
Schnúr et al (2019) Phosphorylation-dependent modulation of CFTR macromolecular signalling complex activity by cigarette smoke condensate in airway epithelia. Sci Rep 9 12706 PMID: 31481727
Liu et al (2016) Inhibition of lysyl oxidase by prostaglandin E2 via EP2/EP4 receptors in human amnion fibroblasts: Implications for parturition. Mol Cell Endocrinol 424 118 PMID: 26826430
Tao et al (2013) cAMP level modulates scleral collagen remodeling, a critical step in the development of myopia. Biochim Biophys Acta 8 e71441 PMID: 23951163
Do you know of a great paper that uses SQ 22536 from Tocris? Please let us know.
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