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Submit ReviewSR 11237
Description: Pan RXR agonist
Alternative Names: BMS 649
Chemical Name: 4-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1,3-dioxolan-2-yl]-benzoic acid
Purity: ≥98% (HPLC)
Biological Activity for SR 11237
SR 11237 is a pan retinoid X receptor (RXR) agonist that is devoid of any RAR activity.
Compound Libraries for SR 11237
SR 11237 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for SR 11237
| M. Wt | 380.48 |
| Formula | C24H28O4 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 146670-40-8 |
| PubChem ID | 127019 |
| InChI Key | ZZUKALQMHNSWTK-UHFFFAOYSA-N |
| Smiles | CC1(C)C2=C(C=CC(C4(OCCO4)C3=CC=C(C(O)=O)C=C3)=C2)C(C)(C)CC1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for SR 11237
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 38.05 | 100 |
Preparing Stock Solutions for SR 11237
The following data is based on the product molecular weight 380.48. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.63 mL | 13.14 mL | 26.28 mL |
| 5 mM | 0.53 mL | 2.63 mL | 5.26 mL |
| 10 mM | 0.26 mL | 1.31 mL | 2.63 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.53 mL |
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Product Datasheets for SR 11237
References for SR 11237
References are publications that support the biological activity of the product.
Chiba et al (1997) Distinct retinoid X receptor-retinoic acid receptor heterodimers are differentially involved in the control of expression of retinoid target genes in F9 embryonal carcinoma cells. Mol.Cell.Biol. 17 3013 PMID: 9154799
Benoit et al (1999) RAR-independent RXR signaling induces t(15;17) leukemia cell maturation. EMBO J. 18 7011 PMID: 10601023
Zhou et al (2010) Retinoid X receptor agonists inhibit phorbol-12-myristate-13-acetate (PMA)-induced differentiation of monocytic THP-1 cells into macrophages. Mol.Cell.Biochem. 335 283 PMID: 19784811
If you know of a relevant reference for SR 11237, please let us know.
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Keywords: SR 11237, SR 11237 supplier, SR11237, BMS649, retinoid, X, receptors, agonist, pan, RXR, RXRalpha, RTXRbeta, RXRgamma, RXRg, RXRa, RXRb, RXRα, RXRβ, RXRγ, BMS, 649, Retinoid, Receptor, 3411, Tocris Bioscience
1 Citation for SR 11237
Citations are publications that use Tocris products. Selected citations for SR 11237 include:
Halstead et al (2017) Bladder-cancer-associated mutations in RXRA activate peroxisome proliferator-activated receptors to drive urothelial proliferation. Elife 6 PMID: 29143738
Do you know of a great paper that uses SR 11237 from Tocris? Please let us know.
Reviews for SR 11237
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Retinoid Receptors Scientific Review
Written by Alexander Moise, this review summarizes the nature of retinoid receptors, their isotype and isoform variants and modulation of retinoid signaling. Compounds available from Tocris are listed.